MicroRNA-23a Promotes Neuroblastoma Cell Metastasis by Targeting CDH1

Overview

Journal Oncol Lett

Specialty Oncology

Date 2014 Feb 13

PMID 24520301

Citations 19

Authors

Lin Cheng

Tao Yang

Yongqin Kuang

Bin Kong

Sixun Yu

Haifeng Shu

Hutian Zhou

Jianwen Gu

Affiliations

Soon will be listed here.

Abstract

CDH1 inactivation is important in tumor metastasis. In the present study, it was suggested that the mRNA and protein levels of CDH1 decreased in metastatic neuroblastoma (NB) tissues compared with those in primary NB tissues. The aim of the study was to explore the regulatory mechanisms of CDH1 downregulation in metastatic NB. MicroRNAs are small non-coding RNAs (~22 nt in length) that negatively regulate target mRNAs and are involved in various cancer-related processes, including metastasis. In the current study, miR-23a was shown to be upregulated in human metastatic NB tissues compared with primary NB tissues. Inhibition of miR-23a may significantly suppress NB cell migration and invasion. reporter assay suggested that CDH1 is a direct target gene of miR-23a. Furthermore, blocking the expression of miR-23a partly restored the expression of CDH1 in NB cells. These findings provide evidence that miR-23a is key in promoting NB cell migration and invasion through targeting CDH1, and suggest that exogenous miR-23a may have therapeutic value in treating NB metastasis.

Citing Articles

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