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Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity

Overview
Journal Biomed Res Int
Publisher Wiley
Date 2014 Feb 12
PMID 24516855
Citations 175
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Abstract

Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored.

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References
1.
Goyer R . Transplacental transport of lead. Environ Health Perspect. 1990; 89:101-5. PMC: 1567784. DOI: 10.1289/ehp.9089101. View

2.
Ehle A, MCKEE D . Neuropsychological effect of lead in occupationally exposed workers: a critical review. Crit Rev Toxicol. 1990; 20(4):237-55. DOI: 10.3109/10408449009089864. View

3.
Khalil N, Morrow L, Needleman H, Talbott E, Wilson J, Cauley J . Association of cumulative lead and neurocognitive function in an occupational cohort. Neuropsychology. 2009; 23(1):10-9. DOI: 10.1037/a0013757. View

4.
Fulton M, Raab G, Thomson G, Laxen D, Hunter R, Hepburn W . Influence of blood lead on the ability and attainment of children in Edinburgh. Lancet. 1987; 1(8544):1221-6. DOI: 10.1016/s0140-6736(87)92683-3. View

5.
Kumar S, Jain S, Aggarwal C, Ahuja G . Encephalopathy due to inorganic lead exposure in an adult. Jpn J Med. 1987; 26(2):253-4. DOI: 10.2169/internalmedicine1962.26.253. View