The Relationship Between Gastroesophageal Reflux Disease and Chronic Periodontitis

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2014 Feb 12

PMID 24516699

Citations 19

Authors

Jun Young Song

Hyung Hun Kim

Eun Ju Cho

Tae Yun Kim

Affiliations

Soon will be listed here.

Abstract

Background/aims: The most common cause of chronic periodontitis is poor oral hygiene. Gastroesophageal reflux disease (GERD) enhances the proximal migration of gastric contents and may cause poor oral hygiene. We hypothesized that GERD may increase the risk of chronic periodontitis and investigated this potential relationship.

Methods: A retrospective cross-sectional study was conducted in outpatients between January 1, 2010, and April 30, 2012. GERD was defined as being present based on at least two of the following criteria: etiologic agent(s), identifiable signs and symptoms, and consistent anatomic alterations. A total of 280 patients with chronic periodontitis and 280 controls were analyzed. Information regarding patient demographics and other potential confounding factors for chronic periodontitis were collected through individual medical records.

Results: GERD was revealed to be independently associated with an increased incidence of chronic periodontitis (odds ratio [OR], 2.883; 95% confidence interval [CI], 1.775 to 4.682). The other three variables of dental caries (OR, 1.531; 95% CI, 1.042 to 2.249), tobacco use (OR, 2.335; 95% CI, 1.461 to 3.730), and history of medication (calcium channel blocker, cyclosporine, or phenytoin) (OR, 2.114; 95% CI, 1.160 to 3.854) were also determined to be independent risk factors.

Conclusions: The present study supported our hypothesis that GERD can be a risk factor for chronic periodontitis.

Citing Articles

Association Between Gastroesophageal Reflux Disease and Periodontitis: A Longitudinal Follow-Up Study from the Korean National Health Screening Cohort.

Lee N, Han K, Yoo D, Kang H, Kim J, Kim J Biomedicines. 2024; 12(11).

PMID: 39595057 PMC: 11591970. DOI: 10.3390/biomedicines12112491.

Identifying causal relationships between gastroesophageal reflux and extraesophageal diseases: A Mendelian randomization study.

Yao P, Liao X, Huang J, Dang Y, Jiang H Medicine (Baltimore). 2024; 103(7):e37054.

PMID: 38363933 PMC: 10869099. DOI: 10.1097/MD.0000000000037054.

Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness.

Patridge E, Gorakshakar A, Molusky M, Ogundijo O, Janevski A, Julian C Comput Struct Biotechnol J. 2024; 23:834-842.

PMID: 38328005 PMC: 10847690. DOI: 10.1016/j.csbj.2024.01.018.

The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other?.

Tamiya H, Abe M, Nagase T, Mitani A J Clin Med. 2023; 12(21).

PMID: 37959214 PMC: 10650117. DOI: 10.3390/jcm12216747.

Dental evaluation is helpful in the differentiation of functional heartburn and gastroesophageal reflux disease.

Helle K, Arok A, Olle G, Antal M, Rosztoczy A World J Gastroenterol. 2023; 29(31):4774-4782.

PMID: 37664156 PMC: 10473917. DOI: 10.3748/wjg.v29.i31.4774.

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