Targeting of Diacerein Loaded Lipid Nanoparticles to Intra-articular Cartilage Using Chondroitin Sulfate As Homing Carrier for Treatment of Osteoarthritis in Rats

From The Clinical Editor: This study demonstrates the feasibility of targeted delivery of diacerein to articular tissue using soluble polysaccharide chondroitin sulfate as the targeting vector. This approach has the potential to significantly increase anti-arthritic drug concentration in joints without leading to systemic toxicity.