Nanoparticles for Multimodal in Vivo Imaging in Nanomedicine

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2014 Feb 11

PMID 24511229

Citations 79

Authors

Jaehong Key

James F Leary

Affiliations

Soon will be listed here.

Abstract

While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.

Citing Articles

Evaluation of Advanced Nanomaterials for Cancer Diagnosis and Treatment.

Ndlovu N, Mdlalose W, Ntsendwana B, Moyo T Pharmaceutics. 2024; 16(4).

PMID: 38675134 PMC: 11054857. DOI: 10.3390/pharmaceutics16040473.

Facile synthesis of Gd/Ru-doped fluorescent carbon dots for fluorescent/MR bimodal imaging and tumor therapy.

Shi Y, Xia Y, Zhou M, Wang Y, Bao J, Zhang Y J Nanobiotechnology. 2024; 22(1):88.

PMID: 38431629 PMC: 10908135. DOI: 10.1186/s12951-024-02360-4.

Core-Shell Nanoparticles for Pulmonary Drug Delivery.

Ratnaparkhi M, Salvankar S, Tekade A, Kulkarni G Pharm Nanotechnol. 2024; 13(1):90-116.

PMID: 38265371 DOI: 10.2174/0122117385277725231120043600.

Modulation of macrophage polarization by iron-based nanoparticles.

Ding H, Zhang Y, Mao Y, Li Y, Shen Y, Sheng J Med Rev (2021). 2023; 3(2):105-122.

PMID: 37724082 PMC: 10471121. DOI: 10.1515/mr-2023-0002.

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges.

Luo Q, Shao N, Zhang A, Chen C, Wang D, Luo L Pharmaceuticals (Basel). 2023; 16(2).

PMID: 37259396 PMC: 9965384. DOI: 10.3390/ph16020249.

References

Skajaa T, Cormode D, Falk E, Mulder W, Fisher E, Fayad Z . High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis. Arterioscler Thromb Vasc Biol. 2009; 30(2):169-76. PMC: 2826843. DOI: 10.1161/ATVBAHA.108.179275. View

Lee N, Choi Y, Lee Y, Park M, Moon W, Choi S . Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r₂ relaxivity for highly sensitive in vivo MRI of tumors. Nano Lett. 2012; 12(6):3127-31. DOI: 10.1021/nl3010308. View

Zhu H, Jones C, van Zijl P, Barker P, Zhou J . Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain. Magn Reson Med. 2010; 64(3):638-44. PMC: 2932772. DOI: 10.1002/mrm.22546. View

Weissleder R, Pittet M . Imaging in the era of molecular oncology. Nature. 2008; 452(7187):580-9. PMC: 2708079. DOI: 10.1038/nature06917. View

Roberts H, Saeed M, Roberts T, Muhler A, Shames D, Mann J . Comparison of albumin-(Gd-DTPA)30 and Gd-DTPA-24-cascade-polymer for measurements of normal and abnormal microvascular permeability. J Magn Reson Imaging. 1997; 7(2):331-8. DOI: 10.1002/jmri.1880070213. View

Michalet X, Pinaud F, Bentolila L, Tsay J, Doose S, Li J . Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005; 307(5709):538-44. PMC: 1201471. DOI: 10.1126/science.1104274. View

Pichler B, Judenhofer M, Pfannenberg C . Multimodal imaging approaches: PET/CT and PET/MRI. Handb Exp Pharmacol. 2008; (185 Pt 1):109-32. DOI: 10.1007/978-3-540-72718-7_6. View

Park J, An K, Hwang Y, Park J, Noh H, Kim J . Ultra-large-scale syntheses of monodisperse nanocrystals. Nat Mater. 2004; 3(12):891-5. DOI: 10.1038/nmat1251. View

Kim D, Park S, Lee J, Jeong Y, Jon S . Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J Am Chem Soc. 2007; 129(24):7661-5. DOI: 10.1021/ja071471p. View

10.

Strijckmans K . The isochronous cyclotron: principles and recent developments. Comput Med Imaging Graph. 2001; 25(2):69-78. DOI: 10.1016/s0895-6111(00)00056-2. View

11.

Caravan P . Strategies for increasing the sensitivity of gadolinium based MRI contrast agents. Chem Soc Rev. 2006; 35(6):512-23. DOI: 10.1039/b510982p. View

12.

Massoud T, Gambhir S . Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003; 17(5):545-80. DOI: 10.1101/gad.1047403. View

13.

Licha K, Olbrich C . Optical imaging in drug discovery and diagnostic applications. Adv Drug Deliv Rev. 2005; 57(8):1087-108. DOI: 10.1016/j.addr.2005.01.021. View

14.

Day S, Kettunen M, Gallagher F, Hu D, Lerche M, Wolber J . Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med. 2007; 13(11):1382-7. DOI: 10.1038/nm1650. View

15.

Rabin O, Perez J, Grimm J, Wojtkiewicz G, Weissleder R . An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater. 2006; 5(2):118-22. DOI: 10.1038/nmat1571. View

16.

Cai Q, Kim S, Choi K, Kim S, Byun S, Kim K . Colloidal gold nanoparticles as a blood-pool contrast agent for X-ray computed tomography in mice. Invest Radiol. 2007; 42(12):797-806. DOI: 10.1097/RLI.0b013e31811ecdcd. View

17.

Wang F, Banerjee D, Liu Y, Chen X, Liu X . Upconversion nanoparticles in biological labeling, imaging, and therapy. Analyst. 2010; 135(8):1839-54. DOI: 10.1039/c0an00144a. View

18.

Kim D, Yu M, Lee T, Park J, Jeong Y, Jon S . Amphiphilic polymer-coated hybrid nanoparticles as CT/MRI dual contrast agents. Nanotechnology. 2011; 22(15):155101. DOI: 10.1088/0957-4484/22/15/155101. View

19.

Knapp D, Adams L, Degrand A, Niles J, Ramos-Vara J, Weil A . Sentinel lymph node mapping of invasive urinary bladder cancer in animal models using invisible light. Eur Urol. 2007; 52(6):1700-8. PMC: 2385787. DOI: 10.1016/j.eururo.2007.07.007. View

20.

Yu Y, Sun D . Superparamagnetic iron oxide nanoparticle 'theranostics' for multimodality tumor imaging, gene delivery, targeted drug and prodrug delivery. Expert Rev Clin Pharmacol. 2011; 3(1):117-30. DOI: 10.1586/ecp.09.39. View