Dealing with Environmental Challenges: Mechanisms of Adaptation in Trypanosoma Cruzi

Overview

Journal Res Microbiol

Publisher Elsevier

Specialty Microbiology

Date 2014 Feb 11

PMID 24508488

Citations 22

Authors

Veronica Jimenez

Affiliations

Soon will be listed here.

Abstract

Protozoan parasites have a significant impact upon global health, infecting millions of people around the world. With limited therapeutic options and no vaccines available, research efforts are focused upon unraveling cellular mechanisms essential for parasite survival. During its life cycle, Trypanosoma cruzi, the causal agent of Chagas disease, is exposed to multiple external conditions and different hosts. Environmental cues are linked to the differentiation process allowing the parasite to complete its life cycle. Successful transmission depends on the ability of the cells to trigger adaptive responses and cope with stressors while regulating proliferation and transition to different life stages. This review focuses upon different aspects of the stress response in T. cruzi, proposing new hypotheses regarding cross-talk and cross-tolerance with respect to environmental changes and discussing open questions and future directions.

Citing Articles

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