Tetraspanin Proteins Promote Multiple Cancer Stages

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2014 Feb 8

PMID 24505619

Citations 185

Authors

Martin E Hemler

Affiliations

Soon will be listed here.

Abstract

An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer. Many studies show that the expression of tetraspanins correlates with tumour stage, tumour type and patient outcome. In addition, perturbations of tetraspanins in tumour cell lines can considerably affect cell growth, morphology, invasion, tumour engraftment and metastasis. This Review emphasizes new studies that have used de novo mouse cancer models to show that select tetraspanin proteins have key roles in tumour initiation, promotion and metastasis. This Review also emphasizes how tetraspanin proteins can sometimes participate in tumour angiogenesis. These recent data build an increasingly strong case for tetraspanins as therapeutic targets.

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