Participation of Capsaicin-sensitive Neurons in the Cardiovascular Effects of Neurotensin in Guinea Pigs

Overview

Journal Peptides

Specialty Biochemistry

Date 1987 Nov 1

PMID 2450340

Citations 3

Authors

H BACHELARD

S St-Pierre

F Rioux

Affiliations

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Abstract

Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic and chronotropic effect. Both effects were completely abolished in atria derived from capsaicin-treated guinea pigs. The positive inotropic and chronotropic effects of NT in guinea pig atria were mimicked by capsaicin and calcitonin gene-related peptide (CGRP). These results were interpreted as an indication that NT produces its cardiovascular effects in guinea pigs by activating capsaicin-sensitive sensory neurons.

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