Hilar Mossy Cells Provide the First Glutamatergic Synapses to Adult-born Dentate Granule Cells

Overview

Journal J Neurosci

Specialty Neurology

Date 2014 Feb 7

PMID 24501373

Citations 51

Authors

Jessica H Chancey

David J Poulsen

Jacques I Wadiche

Linda Overstreet-Wadiche

Affiliations

Soon will be listed here.

Abstract

Adult-generated granule cells (GCs) in the dentate gyrus must establish synapses with preexisting neurons to participate in network activity. To determine the source of early glutamatergic synapses on newborn GCs in adult mice, we examined synaptic currents at the developmental stage when NMDA receptor-mediated silent synapses are first established. We show that hilar mossy cells provide initial glutamatergic synapses as well as disynaptic GABAergic input to adult-generated dentate GCs.

Citing Articles

Field EPSPs of Dentate Gyrus Granule Cells Studied by Selective Optogenetic Activation of Hilar Mossy Cells in Hippocampal Slices.

Bernstein H, Lu Y, Botterill J, Duffy A, LaFrancois J, Scharfman H Hippocampus. 2024; 35(1):e23652.

PMID: 39665517 PMC: 11658804. DOI: 10.1002/hipo.23652.

Increasing adult-born neurons protects mice from epilepsy.

Jain S, LaFrancois J, Gerencer K, Botterill J, Kennedy M, Criscuolo C Elife. 2024; 12.

PMID: 39446467 PMC: 11501206. DOI: 10.7554/eLife.90893.

Intrinsic and Synaptic Contributions to Repetitive Spiking in Dentate Granule Cells.

Shu W, Jackson M J Neurosci. 2024; 44(18).

PMID: 38503495 PMC: 11063872. DOI: 10.1523/JNEUROSCI.0716-23.2024.

Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model.

Deng P, Kumar A, Cavalli V, Klyachko V Elife. 2024; 12.

PMID: 38345852 PMC: 10942577. DOI: 10.7554/eLife.92563.

Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility.

Li H, Tamura R, Hayashi D, Asai H, Koga J, Ando S Sci Adv. 2024; 10(2):eadk4741.

PMID: 38198539 PMC: 10780870. DOI: 10.1126/sciadv.adk4741.

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