Red Blood Cell Distribution Width is Not Correlated with Preeclampsia Among Pregnant Sudanese Women

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2014 Feb 7

PMID 24499498

Citations 11

Authors

Hala Abdullahi

Ameer Osman

Duria A Rayis

Gasim I Gasim

Abdulmutalab M Imam

Ishag Adam

Affiliations

Soon will be listed here.

Abstract

Background: Preeclampsia is a leading cause of maternal and perinatal mortality worldwide. The exact etiology of preeclampsia is unknown, but the inflammatory process is postulated as one of the etiologies. Red blood cell distribution width (RDW) is a measure of anisocytosis (variation of red cell size) and is associated with hypertension and diabetic ketoacidosis. There are few data on the association between RDW and preeclampsia. This study aimed to investigate the association between RDW and preeclampsia.

Methods: A case-control study was conducted at Khartoum Hospital, Sudan, during June to August 2012. Cases were women with preeclampsia and healthy women were controls. Sociodemographic characteristics, obstetrics, and clinical data were recorded. The complete blood count, including RDW, was measured using an automated hematology analyzer.

Results: The cases and controls (65 women in each arm) were matched in their basic characteristics. There was no difference in the mean (SD) RDW between women with preeclampsia and controls (14.5 ± 1.8% vs. 14.4 ± 1.4%, P = 0.710). There was also no difference in the mean RDW between women with mild and severe preeclampsia (14.7 ± 1.9% vs. 13.9 ± 1.4%, P = 0.144. In logistic regression, there was no association between RDW and preeclampsia (OR = 0.9, CI = 0.7-1.1, P = 0.952).

Conclusions: RDW levels are not associated with the presence or severity of preeclampsia.

Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1206247718115175.

Citing Articles

A Case-Control Study Utilizing Red Cell Distribution Width as a Bio-Inflammatory Marker in Pre-eclampsia.

Singhal K, Gupta S, Tiwari S, Pinjar M Cureus. 2024; 16(3):e55910.

PMID: 38601404 PMC: 11003858. DOI: 10.7759/cureus.55910.

The association between red cell distribution width and newly diagnosed hypertension among adults in Northern Sudan: a case-control study.

Hassan A, Musa S, Omer H, Adam I Libyan J Med. 2023; 18(1):2254502.

PMID: 37665970 PMC: 10478621. DOI: 10.1080/19932820.2023.2254502.

New indicators in evaluation of hemolysis, elevated liver enzymes, and low platelet syndrome: A case-control study.

Kang S, Wang Y, Zhou L, Zhang H World J Clin Cases. 2021; 9(6):1259-1270.

PMID: 33644193 PMC: 7896688. DOI: 10.12998/wjcc.v9.i6.1259.

Red cell distribution width and preeclampsia: a systematic review and meta-analysis.

Adam I, Mutabingwa T, Malik E Clin Hypertens. 2019; 25:15.

PMID: 31338207 PMC: 6628484. DOI: 10.1186/s40885-019-0119-7.

Hypertensive disorders of pregnancy are associated with an inflammatory state: evidence from hematological findings and cytokine levels.

Mtali Y, Lyimo M, Luzzatto L, Massawe S BMC Pregnancy Childbirth. 2019; 19(1):237.

PMID: 31288789 PMC: 6617701. DOI: 10.1186/s12884-019-2383-7.

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