The Skin As an Immunologic Organ

Overview

Journal Arch Pathol Lab Med

Specialty Pathology

Date 1988 Mar 1

PMID 2449876

Citations 8

Authors

S Shimada

S I Katz

Affiliations

Soon will be listed here.

Abstract

The epidermis is a heterogeneous tissue comprised of cells that may play a role in various types of immunologic responses. This review focuses on the importance of epidermal Langerhans' cells in antigen presenting and accessory cell functions, on the role of la-positive keratinocytes in generating certain types of immune responses, on the role of normal keratinocytes in the liberation of cytokines, on the identification of murine Thy-1-bearing dendritic epidermal cells, and on the modulation of epidermal immune functions by various physical and chemical agents.

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