JMJD6 Regulates ERα Methylation on Arginine

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Feb 6

PMID 24498420

Citations 53

Authors

Coralie Poulard

Juliette Rambaud

Nader Hussein

Laura Corbo

Muriel Le Romancer

Affiliations

Soon will be listed here.

Abstract

ERα functions are tightly controlled by numerous post-translational modifications including arginine methylation, which is required to mediate the extranuclear functions of the receptor. We report that upon oestrogenic stimulation, JMJD6, the only arginine demethylase described so far, interacts with and regulates methylated ERα (metERα) function. Moreover, by combining the silencing of JMJD6 with demethylation assays, we show that metERα is a new substrate for JMJD6. We propose that the demethylase activity of JMJD6 is a decisive regulator of the rapid physiological responses to oestrogen.

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