Comparison of Method of Conception in Fetuses Undergoing Echocardiography at a Tertiary Referral Center

Overview

Journal Prenat Diagn

Publisher Wiley

Specialty Gynecology & Obstetrics

Date 2014 Feb 6

PMID 24496858

Citations 5

Authors

Jodie K Votava-Smith

Julie S Glickstein

Lynn L Simpson

Ismee A Williams

Affiliations

Soon will be listed here.

Abstract

Objectives: We compared the proportion of conception with and without in vitro fertilization (IVF) in fetuses with and without congenital heart disease (CHD).

Methods: This was a retrospective review of fetal echocardiograms at Columbia University from 2007 to 2010, to identify the mode of conception.

Results: Echocardiography was performed on 2828 fetuses, and 2761 (97.6%) had the method of conception documented. CHD was diagnosed in 22.4%, consisting predominantly of complex CHD. The proportion of IVF conception was lower in fetuses with CHD (6.9% CHD vs 10.3% no CHD, OR = 0.65 [95% CI 0.46-0.92], p = 0.01). IVF fetuses were conceived by elder mothers and were more likely part of a multiple gestation than those without IVF. In a multivariate model controlling for maternal age and multiple gestation, IVF was not associated with CHD diagnosis (OR = 1.1 [95% CI 0.77-1.7], p = 0.51).

Conclusion: At a tertiary referral center, fetuses with CHD were not more likely to be conceived by IVF after controlling for maternal age and multiple gestation. These results differ from those of several previous reports, which may be related to our study population, and the exclusion of isolated atrial shunts and patent ductus arteriosus, which are normal fetal findings.

Citing Articles

Congenital Heart Defects in Pregnancies Conceived by Assisted Reproductive Technology: Comparing Functional and Structural Defects.

Rasouli S, Radgoodarzi M, Azarbad R, Ghazvini A, Sotoudeheian M, Taghizadeh M Cureus. 2024; 16(2):e54810.

PMID: 38529454 PMC: 10961672. DOI: 10.7759/cureus.54810.

Assisted Reproductive Techniques and Risk of Congenital Heart Diseases in Children: a Systematic Review and Meta-analysis.

Gullo G, Scaglione M, Lagana A, Perino A, Andrisani A, Chiantera V Reprod Sci. 2023; 30(10):2896-2906.

PMID: 37145300 PMC: 10556115. DOI: 10.1007/s43032-023-01252-6.

Correlation between assisted reproductive technology-induced pregnancy and fetal cardiac anomalies.

Zargar M, Rahimi M, Barati M, Moramazi F, Emami Moghadam A, Choghakabodi P JBRA Assist Reprod. 2021; 26(2):329-334.

PMID: 34709775 PMC: 9118956. DOI: 10.5935/1518-0557.20210088.

Associations of Assisted Reproductive Technology and Twin Pregnancy With Risk of Congenital Heart Defects.

Wen S, Miao Q, Taljaard M, Lougheed J, Gaudet L, Davies M JAMA Pediatr. 2020; 174(5):446-454.

PMID: 32091547 PMC: 7042937. DOI: 10.1001/jamapediatrics.2019.6096.

The Fetus with Ectopia Cordis: Experience and Expectations from Two Centers.

Escobar-Diaz M, Sunderji S, Tworetzky W, Moon-Grady A Pediatr Cardiol. 2016; 38(3):531-538.

PMID: 27995289 DOI: 10.1007/s00246-016-1545-x.

References

Davies M, Moore V, Willson K, van Essen P, Priest K, Scott H . Reproductive technologies and the risk of birth defects. N Engl J Med. 2012; 366(19):1803-13. DOI: 10.1056/NEJMoa1008095. View

Hansen M, Kurinczuk J, Bower C, Webb S . The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002; 346(10):725-30. DOI: 10.1056/NEJMoa010035. View

Buss C, Davis E, Hobel C, Sandman C . Maternal pregnancy-specific anxiety is associated with child executive function at 6-9 years age. Stress. 2011; 14(6):665-76. PMC: 3222921. DOI: 10.3109/10253890.2011.623250. View

Roguin N, Du Z, Barak M, Nasser N, Hershkowitz S, MILGRAM E . High prevalence of muscular ventricular septal defect in neonates. J Am Coll Cardiol. 1995; 26(6):1545-8. DOI: 10.1016/0735-1097(95)00358-4. View

Koivurova S, Hartikainen A, Gissler M, Hemminki E, Sovio U, Jarvelin M . Neonatal outcome and congenital malformations in children born after in-vitro fertilization. Hum Reprod. 2002; 17(5):1391-8. DOI: 10.1093/humrep/17.5.1391. View

Paladini D, Palmieri S, Lamberti A, Teodoro A, Martinelli P, Nappi C . Characterization and natural history of ventricular septal defects in the fetus. Ultrasound Obstet Gynecol. 2000; 16(2):118-22. DOI: 10.1046/j.1469-0705.2000.00202.x. View

. AIUM practice guideline for the performance of fetal echocardiography. J Ultrasound Med. 2011; 30(1):127-36. DOI: 10.7863/jum.2011.30.1.127. View

Connuck D, Sun J, Super D, Kirchner H, Fradley L, Salvator A . Incidence of patent ductus arteriosus and patent foramen ovale in normal infants. Am J Cardiol. 2002; 89(2):244-7. PMC: 10246183. DOI: 10.1016/s0002-9149(01)02214-7. View

Olson C, Keppler-Noreuil K, Romitti P, Budelier W, Ryan G, Sparks A . In vitro fertilization is associated with an increase in major birth defects. Fertil Steril. 2005; 84(5):1308-15. DOI: 10.1016/j.fertnstert.2005.03.086. View

10.

Reefhuis J, Honein M, Schieve L, Correa A, Hobbs C, Rasmussen S . Assisted reproductive technology and major structural birth defects in the United States. Hum Reprod. 2008; 24(2):360-6. DOI: 10.1093/humrep/den387. View

11.

Wen S, Leader A, White R, Leveille M, Wilkie V, Zhou J . A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection. Eur J Obstet Gynecol Reprod Biol. 2010; 150(2):160-5. DOI: 10.1016/j.ejogrb.2010.02.028. View

12.

Ericson A, Kallen B . Congenital malformations in infants born after IVF: a population-based study. Hum Reprod. 2001; 16(3):504-9. DOI: 10.1093/humrep/16.3.504. View

13.

Rosenberg K, Monk C, Glickstein J, Levasseur S, Simpson L, Kleinman C . Referral for fetal echocardiography is associated with increased maternal anxiety. J Psychosom Obstet Gynaecol. 2010; 31(2):60-9. PMC: 2866143. DOI: 10.3109/01674821003681472. View

14.

Sunderam S, Kissin D, Flowers L, Anderson J, Folger S, Jamieson D . Assisted reproductive technology surveillance--United States, 2009. MMWR Surveill Summ. 2012; 61(7):1-23. View

15.

. Births in Great Britain resulting from assisted conception, 1978-87. MRC Working Party on Children Conceived by In Vitro Fertilisation. BMJ. 1990; 300(6734):1229-33. PMC: 1662883. DOI: 10.1136/bmj.300.6734.1229. View

16.

Anthony S, Buitendijk S, Dorrepaal C, Lindner K, Braat D, den Ouden A . Congenital malformations in 4224 children conceived after IVF. Hum Reprod. 2002; 17(8):2089-95. DOI: 10.1093/humrep/17.8.2089. View

17.

Allen V, Wilson R, Cheung A . RETIRED: Pregnancy outcomes after assisted reproductive technology. J Obstet Gynaecol Can. 2006; 28(3):220-233. DOI: 10.1016/S1701-2163(16)32112-0. View

18.

Rychik J, Ayres N, Cuneo B, Gotteiner N, Hornberger L, Spevak P . American Society of Echocardiography guidelines and standards for performance of the fetal echocardiogram. J Am Soc Echocardiogr. 2004; 17(7):803-10. DOI: 10.1016/j.echo.2004.04.011. View