How to Make an Intestine

Overview

Journal Development

Specialty Biology

Date 2014 Feb 6

PMID 24496613

Citations 90

Authors

James M Wells

Jason R Spence

Affiliations

Soon will be listed here.

Abstract

With the high prevalence of gastrointestinal disorders, there is great interest in establishing in vitro models of human intestinal disease and in developing drug-screening platforms that more accurately represent the complex physiology of the intestine. We will review how recent advances in developmental and stem cell biology have made it possible to generate complex, three-dimensional, human intestinal tissues in vitro through directed differentiation of human pluripotent stem cells. These are currently being used to study human development, genetic forms of disease, intestinal pathogens, metabolic disease and cancer.

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