Substance P Modulates the Release of Locally Synthesized Nerve Growth Factor from Rat Saphenous Nerve Neuroma

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1987 Nov 1

PMID 2449623

Citations 2

Authors

D M White

P Ehrhard

M Hardung

D K Meyer

M Zimmermann

U Otten

Affiliations

Soon will be listed here.

Abstract

In saphenous nerve neuromata of adult rats a long-term increase of immunoreactive nerve growth factor (irNGF) was detected after nerve transection. The occurrence of messenger RNA encoding NGF (NGF mRNA) in these proximal nerve stumps indicates local biosynthesis of NGF. In situ superfusion of neuromata revealed a constant release of irNGF which was significantly reduced by substance P (SP) but not affected by calcitonin gene related peptide (CGRP). We therefore suggest that SP may modulate the availability of NGF in the microenvironment of the regenerating nerve fiber endings.

Citing Articles

Nerve Growth Factor: Early Studies and Recent Clinical Trials.

Rocco M, Soligo M, Manni L, Aloe L Curr Neuropharmacol. 2018; 16(10):1455-1465.

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Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity.

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References

Lee Y, Takami K, Kawai Y, Girgis S, Hillyard C, MacIntyre I . Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P. Neuroscience. 1985; 15(4):1227-37. DOI: 10.1016/0306-4522(85)90265-9. View

Hokfelt T, Millhorn D, Seroogy K, Tsuruo Y, Ceccatelli S, Lindh B . Coexistence of peptides with classical neurotransmitters. Experientia. 1987; 43(7):768-80. DOI: 10.1007/BF01945354. View

Skofitsch G, Donnerer J, Petronijevic S, Saria A, Lembeck F . Release of histamine by neuropeptides from the perfused rat hindquarter. Naunyn Schmiedebergs Arch Pharmacol. 1983; 322(2):153-7. DOI: 10.1007/BF00512389. View

Weskamp G, LOREZ H, Keller H, Otten U . Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex. Naunyn Schmiedebergs Arch Pharmacol. 1986; 334(4):346-51. DOI: 10.1007/BF00569368. View

Melton D, Krieg P, Rebagliati M, Maniatis T, Zinn K, Green M . Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 1984; 12(18):7035-56. PMC: 320141. DOI: 10.1093/nar/12.18.7035. View

Cheley S, Anderson R . A reproducible microanalytical method for the detection of specific RNA sequences by dot-blot hybridization. Anal Biochem. 1984; 137(1):15-9. DOI: 10.1016/0003-2697(84)90339-7. View

Scott J, Selby M, Urdea M, Quiroga M, Bell G, Rutter W . Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature. 1983; 302(5908):538-40. DOI: 10.1038/302538a0. View

Holzer-Petsche U, Schimek E, Amann R, Lembeck F . In vivo and in vitro actions of mammalian tachykinins. Naunyn Schmiedebergs Arch Pharmacol. 1985; 330(2):130-5. DOI: 10.1007/BF00499905. View

Shehab S, Atkinson M . Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons. Brain Res. 1986; 372(1):37-44. DOI: 10.1016/0006-8993(86)91456-3. View

10.

Weskamp G, Otten U . An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissues. J Neurochem. 1987; 48(6):1779-86. DOI: 10.1111/j.1471-4159.1987.tb05736.x. View

11.

Hartung H, Wolters K, Toyka K . Substance P: binding properties and studies on cellular responses in guinea pig macrophages. J Immunol. 1986; 136(10):3856-63. View

12.

Heumann R, Korsching S, Bandtlow C, Thoenen H . Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection. J Cell Biol. 1987; 104(6):1623-31. PMC: 2114490. DOI: 10.1083/jcb.104.6.1623. View

13.

Davies A, Bandtlow C, Heumann R, Korsching S, Rohrer H, Thoenen H . Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor. Nature. 1987; 326(6111):353-8. DOI: 10.1038/326353a0. View

14.

Jessell T, Tsunoo A, Kanazawa I, Otsuka M . Substance P: depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons. Brain Res. 1979; 168(2):247-59. DOI: 10.1016/0006-8993(79)90167-7. View

15.

Lehrach H, Diamond D, Wozney J, Boedtker H . RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry. 1977; 16(21):4743-51. DOI: 10.1021/bi00640a033. View

16.

Rush R . Immunohistochemical localization of endogenous nerve growth factor. Nature. 1984; 312(5992):364-7. DOI: 10.1038/312364a0. View

17.

Lembeck F, Gamse R . Substance P in peripheral sensory processes. Ciba Found Symp. 1982; (91):35-54. DOI: 10.1002/9780470720738.ch4. View

18.

Heumann R, Korsching S, Scott J, Thoenen H . Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues. EMBO J. 1984; 3(13):3183-9. PMC: 557836. DOI: 10.1002/j.1460-2075.1984.tb02277.x. View

19.

Thoenen H, Barde Y . Physiology of nerve growth factor. Physiol Rev. 1980; 60(4):1284-335. DOI: 10.1152/physrev.1980.60.4.1284. View

20.

Senapati A, Anand P, McGregor G, Ghatei M, Thompson R, Bloom S . Depletion of neuropeptides during wound healing in rat skin. Neurosci Lett. 1986; 71(1):101-5. DOI: 10.1016/0304-3940(86)90264-8. View