Ion Channels and Transporters in Tumour Cell Migration and Invasion

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2014 Feb 5

PMID 24493750

Citations 65

Authors

Albrecht Schwab

Christian Stock

Affiliations

Soon will be listed here.

Abstract

Cell migration is a central component of the metastatic cascade requiring a concerted action of ion channels and transporters (migration-associated transportome), cytoskeletal elements and signalling cascades. Ion transport proteins and aquaporins contribute to tumour cell migration and invasion among other things by inducing local volume changes and/or by modulating Ca(2+) and H(+) signalling. Targeting cell migration therapeutically bears great clinical potential, because it is a prerequisite for metastasis. Ion transport proteins appear to be attractive candidate target proteins for this purpose because they are easily accessible as membrane proteins and often overexpressed or activated in cancer. Importantly, a number of clinically widely used drugs are available whose anticipated efficacy as anti-tumour drugs, however, has now only begun to be evaluated.

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References

Busco G, Cardone R, Greco M, Bellizzi A, Colella M, Antelmi E . NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space. FASEB J. 2010; 24(10):3903-15. DOI: 10.1096/fj.09-149518. View

Yang S, Zhang J, Huang X . Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell. 2009; 15(2):124-34. DOI: 10.1016/j.ccr.2008.12.019. View

Webb B, Chimenti M, Jacobson M, Barber D . Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer. 2011; 11(9):671-7. DOI: 10.1038/nrc3110. View

Schneider S, Pagel P, Rotsch C, Danker T, Oberleithner H, Radmacher M . Volume dynamics in migrating epithelial cells measured with atomic force microscopy. Pflugers Arch. 2000; 439(3):297-303. DOI: 10.1007/s004249900176. View

Egeblad M, Nakasone E, Werb Z . Tumors as organs: complex tissues that interface with the entire organism. Dev Cell. 2010; 18(6):884-901. PMC: 2905377. DOI: 10.1016/j.devcel.2010.05.012. View

Wei C, Wang X, Chen M, Ouyang K, Song L, Cheng H . Calcium flickers steer cell migration. Nature. 2009; 457(7231):901-5. PMC: 3505761. DOI: 10.1038/nature07577. View

Szablewski L . Expression of glucose transporters in cancers. Biochim Biophys Acta. 2012; 1835(2):164-9. DOI: 10.1016/j.bbcan.2012.12.004. View

Okamoto Y, Ohkubo T, Ikebe T, Yamazaki J . Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int J Oncol. 2012; 40(5):1431-40. DOI: 10.3892/ijo.2012.1340. View

Stock C, Cardone R, Busco G, Krahling H, Schwab A, Reshkin S . Protons extruded by NHE1: digestive or glue?. Eur J Cell Biol. 2008; 87(8-9):591-9. DOI: 10.1016/j.ejcb.2008.01.007. View

10.

Pardo L, del Camino D, Sanchez A, Alves F, Bruggemann A, Beckh S . Oncogenic potential of EAG K(+) channels. EMBO J. 1999; 18(20):5540-7. PMC: 1171622. DOI: 10.1093/emboj/18.20.5540. View

11.

Murphy D, Courtneidge S . The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol. 2011; 12(7):413-26. PMC: 3423958. DOI: 10.1038/nrm3141. View

12.

Monet M, Lehenkyi V, Gackiere F, Firlej V, Vandenberghe M, Roudbaraki M . Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res. 2010; 70(3):1225-35. DOI: 10.1158/0008-5472.CAN-09-2205. View

13.

Chantome A, Potier-Cartereau M, Clarysse L, Fromont G, Marionneau-Lambot S, Gueguinou M . Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases. Cancer Res. 2013; 73(15):4852-61. DOI: 10.1158/0008-5472.CAN-12-4572. View

14.

Hahn K, DeBiasio R, Taylor D . Patterns of elevated free calcium and calmodulin activation in living cells. Nature. 1992; 359(6397):736-8. DOI: 10.1038/359736a0. View

15.

Ataga K, Reid M, Ballas S, Yasin Z, Bigelow C, James L . Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker.... Br J Haematol. 2011; 153(1):92-104. DOI: 10.1111/j.1365-2141.2010.08520.x. View

16.

Erlandsen S, Greet Bittermann A, White J, Leith A, Marko M . High-resolution CryoFESEM of individual cell adhesion molecules (CAMs) in the glycocalyx of human platelets: detection of P-selectin (CD62P), GPI-IX complex (CD42A/CD42B alpha,B beta), and integrin GPIIbIIIa (CD41/CD61) by immunogold labeling and.... J Histochem Cytochem. 2001; 49(7):809-19. DOI: 10.1177/002215540104900702. View

17.

Grinstein S, Woodside M, Waddell T, Downey G, Orlowski J, Pouyssegur J . Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH. EMBO J. 1993; 12(13):5209-18. PMC: 413785. DOI: 10.1002/j.1460-2075.1993.tb06216.x. View

18.

Cuddapah V, Sontheimer H . Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. J Biol Chem. 2010; 285(15):11188-96. PMC: 2856996. DOI: 10.1074/jbc.M109.097675. View

19.

Soroceanu L, Manning Jr T, Sontheimer H . Modulation of glioma cell migration and invasion using Cl(-) and K(+) ion channel blockers. J Neurosci. 1999; 19(14):5942-54. PMC: 6783071. View

20.

Lauritzen G, Stock C, Lemaire J, Lund S, Jensen M, Damsgaard B . The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. Cancer Lett. 2011; 317(2):172-83. DOI: 10.1016/j.canlet.2011.11.023. View