Genetics of Breast Cancer Bone Metastasis: a Sequential Multistep Pattern

Overview

Journal Clin Exp Metastasis

Specialty Oncology

Date 2014 Feb 5

PMID 24493024

Citations 16

Authors

Hassan Fazilaty

Parvin Mehdipour

Affiliations

Soon will be listed here.

Abstract

Bone metastasis accounts for the vast majority of breast cancer (BC) metastases, and is related to a high rate of morbidity and mortality. A number of seminal studies have uncovered gene expression signatures involved in BC development and bone metastasis; each of them points at a distinct step of the 'invasion-metastasis cascade'. In this review, we provide most recently discovered functions of sets of genes that are selected from widely accepted gene signatures that are implicate in BC progression and bone metastasis. We propose a possible sequential pattern of gene expression that may lead a benign primary breast tumor to get aggressiveness and progress toward bone metastasis. A panel of genes which primarily deal with features like DNA replication, survival, proliferation, then, angiogenesis, migration, and invasion has been identified. TGF-β, FGF, NFκB, WNT, PI3K, and JAK-STAT signaling pathways, as the key pathways involved in breast cancer development and metastasis, are evidently regulated by several genes in all three signatures. Epithelial to mesenchymal transition that is also an important mechanism in cancer stem cell generation and metastasis is evidently regulated by these genes. This review provides a comprehensive insight regarding breast cancer bone metastasis that may lead to a better understanding of the disease and take step toward better treatments.

Citing Articles

Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions.

Wang S, Wu W, Lin X, Zhang K, Wu Q, Luo M Cell Biosci. 2023; 13(1):224.

PMID: 38041134 PMC: 10693103. DOI: 10.1186/s13578-023-01171-8.

The relationship between the Hippo signaling pathway and bone metastasis of breast cancer.

Han Q, Qiu S, Hu H, Li W, Dang X, Li X Front Oncol. 2023; 13:1188310.

PMID: 37256184 PMC: 10225633. DOI: 10.3389/fonc.2023.1188310.

Metastatic and non-metastatic melanoma imaging using Sgc8-c aptamer PTK7-recognizer.

Sicco E, Monaco A, Fernandez M, Moreno M, Calzada V, Cerecetto H Sci Rep. 2021; 11(1):19942.

PMID: 34620894 PMC: 8497559. DOI: 10.1038/s41598-021-98828-6.

miRNA-148a and miRNA-30c expressions as potential biomarkers in breast cancer patients.

Elhelbawy N, Zaid I, Khalifa A, Gohar S, Fouda E Biochem Biophys Rep. 2021; 27:101060.

PMID: 34195390 PMC: 8239439. DOI: 10.1016/j.bbrep.2021.101060.

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons.

Guerrieri A, Montesi M, Sprio S, Laranga R, Mercatali L, Tampieri A Front Bioeng Biotechnol. 2020; 8:589964.

PMID: 33123519 PMC: 7573123. DOI: 10.3389/fbioe.2020.589964.

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