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Cellular Reprogramming

Overview
Journal Cold Spring Harb Perspect Biol
Specialties Biology
Molecular Biology
Date 2014 Feb 5
PMID 24492711
Citations 15
Authors
Kazutoshi Takahashi
Affiliations
Soon will be listed here.
Abstract

Nuclear reprogramming technology was first established more than 50 years ago. It can rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new pluripotent order. The recent discovery reviewed here that induced pluripotency can be achieved by a small set of transcription factors has opened up unprecedented opportunities in the pharmaceutical industry, the clinic, and laboratories. This technology allows us to access pathological studies by using patient-specific induced pluripotent stem (iPS) cells. In addition, iPS cells are also expected to be a rising star for regenerative medicine, as sources of transplantation therapy.

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