Young's Modulus of Canine Vocal Fold Cover Layers

Overview

Journal J Voice

Specialty Otorhinolaryngology

Date 2014 Feb 5

PMID 24491497

Citations 17

Authors

Dinesh K Chhetri

Sassan Rafizadeh

Affiliations

Soon will be listed here.

Abstract

Objectives: The objective of this study was to measure the elastic modulus (Young's modulus) of canine vocal fold cover layers.

Study Design: Basic science study.

Methods: Cover layers from vocal folds of eight canine larynges were dissected. Cover layer samples from the mid-membranous, medial vocal fold surface area were used to measure material stiffness using a previously validated indentation method. Cover layers from two human larynges were also measured as control references. Superior and inferior medial cover layers were measured separately. A total of 15 superior medial surface and 17 inferior medial surface specimens from the canine and two and four specimens, respectively, from the human were tested.

Results: In the canine larynges, the mean Young's modulus of the superior medial surface was 4.2 kPa (range, 3.0-5.4 kPa; standard deviation [SD], 0.6 kPa) and of the inferior medial surface was 6.8 kPa (range, 5.4-8.5 kPa; SD, 0.8 kPa). Measurements on human cover samples were 5.0 kPa (range, 4.7-5.4 kPa; SD, 0.5 kPa) and 7.0 kPa (range, 6.7-7.3 kPa; SD, 0.3 kPa) for the superior medial and inferior medial surface, respectively. Human measurements were similar to the previously validated measurements. There was no difference between the stiffness measurements in the human and canine cover layer samples (P>0.05).

Conclusions: The elastic stiffness (Young's modulus) of the canine and human vocal fold cover layers is similar. Findings support the use of canine larynx as an externally valid model to study voice production.

Citing Articles

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Genipin cross-linked gelatin hydrogel for encapsulating wharton jelly mesenchymal stem cells and basic fibroblast growth factor delivery in vocal fold regeneration.

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Comparison of Aerodynamic and Elastic Properties in Tissue and Synthetic Models of Vocal Fold Vibrations.

Michaud-Dorko J, de Luzan C, Dion G, Gutmark E, Oren L Bioengineering (Basel). 2024; 11(8).

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Oren L, Maddox A, de Luzan C, Xie C, Howell R, Dion G Eur Arch Otorhinolaryngol. 2024; 281(5):2523-2529.

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Control of Pre-phonatory Glottal Shape by Intrinsic Laryngeal Muscles.

Pillutla P, Reddy N, Schlegel P, Zhang Z, Chhetri D Laryngoscope. 2022; 133(7):1690-1697.

PMID: 36129162 PMC: 10027621. DOI: 10.1002/lary.30403.

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