Effect of Narrow Band Ultraviolet B Therapy Versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis

Overview

Journal Dermatol Res Pract

Publisher Wiley

Specialty Dermatology

Date 2014 Feb 4

PMID 24489536

Citations 1

Authors

Tarek Mahmoud Elghandour

Sahar El Sayed Youssef

Dalia Gamal Aly

Mohamed Said Abd Elhameed

Mehrevan Mostafa Abdel Moneim

Affiliations

Soon will be listed here.

Abstract

Background. There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patients. Methods. Thirty patients with severe plaque psoriasis were included: 15 patients received NB-UVB three times weekly (group I) and 15 patients received MTX 0.3 mg/kg per week (group II), both for 8 weeks. Before and after treatment, serum levels of IL-17 and IL-23 were investigated by ELISA technique and psoriasis area and severity index (PASI) was calculated. Results. After treatment, all patients showed a reduction in their PASI score, IL-17 and IL-23 serum levels with a nonsignificant difference between both therapeutic modalities (P value >0.05). A positive correlation was detected between the percent of reduction of IL-17, IL-23 and the percent of reduction of PASI score for patients receiving both treatments. No correlation was found between the percent of reduction of IL-17, IL-23 and duration of disease or age of all patients in this study. Conclusion. Interleukin-17 and IL-23 serum level may serve as a potential biomarker for predicting the prognosis and therapeutic response of NB-UVB or MTX in treating psoriasis.

Citing Articles

Achieving sustained minimal disease activity with methotrexate in early interleukin 23-driven early psoriatic arthritis.

den Braanker H, Wervers K, Mus A, Bangoer P, Davelaar N, Luime J RMD Open. 2020; 6(2).

PMID: 32669451 PMC: 7425114. DOI: 10.1136/rmdopen-2020-001175.

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