Five-year Prospective Study of Paediatric Acute Otitis Media in Rochester, NY: Modelling Analysis of the Risk of Pneumococcal Colonization in the Nasopharynx and Infection

Overview

Journal Epidemiol Infect

Publisher Cambridge University Press

Specialties Infectious Diseases
Public Health

Date 2014 Feb 1

PMID 24480055

Citations 15

Authors

V Friedel

S Zilora

D Bogaard

J R Casey

M E Pichichero

Affiliations

Soon will be listed here.

Abstract

During a 5-year prospective study of nasopharyngeal (NP) colonization and acute otitis media (AOM) infections in children during the 7-valent pneumococcal conjugate vaccine (PCV) era (July 2006-June 2011) we studied risk factors for NP colonization and AOM. NP samples were collected at ages 6, 9, 12, 15, 18, 24, and 30 months during well-child visits. Additionally, NP and middle ear fluid (MEF) samples were collected at onset of every AOM episode. From 1825 visits (n = 464 children), 5301 NP and 570 MEF samples were collected and analysed for potential otopathogens. Daycare attendance, NP colonization by Moraxella catarrhalis, and siblings aged <5 years increased the risk of Streptococcus pneumoniae NP colonization. NP colonization with S. pneumoniae, M. catarrhalis, or Haemophilus influenzae and a family history of OM increased the risk of AOM. Risk factors that increase the risk of pneumococcal AOM will be important to reassess as we move into a new 13-valent PCV era, especially co-colonization with other potential otopathogens.

Citing Articles

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Three Innate Cytokine Biomarkers Predict Presence of Acute Otitis Media and Relevant Otopathogens.

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Kaur R, Morris M, E Pichichero M Pediatrics. 2017; 140(3).

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