Waist-to-height Ratio, Inflammation and CVD Risk in Obese Children

Overview

Journal Public Health Nutr

Publisher Cambridge University Press

Date 2014 Jan 31

PMID 24476930

Citations 13

Authors

Josune Olza

Concepcion M Aguilera

Mercedes Gil-Campos

Rosaura Leis

Gloria Bueno

Miguel Valle

Ramon Canete

Rafael Tojo

Luis A Moreno

Angel Gil

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the association between waist-to-height ratio (WHtR) and specific biomarkers of inflammation, CVD risk and endothelial dysfunction in prepubertal obese children.

Design: Prospective, multicentre case-control study matched by age and sex.

Setting: Children were recruited between May 2007 and May 2010 from primary-care centres and schools in three cities in Spain (Cordoba, Santiago de Compostela and Zaragoza).

Subjects: Four hundred and forty-six (223 normal weight and 223 obese) Caucasian prepubertal children aged 6-12 years.

Results: WHtR was higher in the obese than in the normal-weight children. Blood pressure, waist circumference, weight, height, insulin, plasma lipids, leptin, resistin, abnormal neutrophil and monocyte counts, C-reactive protein, IL-6, IL-8, TNF-α, myeloperoxidase, soluble intercellular adhesion molecule-1, selectin and plasminogen activator inhibitor-1 levels were higher in the obese than in the normal-weight group. Adiponectin and HDL-cholesterol were lower and glucose and metalloproteinase-9 showed no differences. Resistin, TNF-α and active plasminogen activator inhibitor-1 were associated with WHtR, a sensitive indicator of central obesity.

Conclusions: Our results lead to the hypothesis that changes in biomarker levels of insulin resistance, inflammation and CVD risk before puberty might induce metabolic consequences of obesity in obese children before reaching adulthood.

Citing Articles

Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk.

Hertis Petek T, Homsak E, Svetej M, Marcun Varda N Biomedicines. 2025; 13(1).

PMID: 39857642 PMC: 11761629. DOI: 10.3390/biomedicines13010058.

Childhood Cardiovascular Health, Obesity, and Some Related Disorders: Insights into Chronic Inflammation and Oxidative Stress.

Hertis Petek T, Marcun Varda N Int J Mol Sci. 2024; 25(17).

PMID: 39273654 PMC: 11396019. DOI: 10.3390/ijms25179706.

Impact of One-Year Dietary Education on Change in Selected Anthropometric and Biochemical Parameters in Children with Excess Body Weight.

Straczek K, Horodnicka-Jozwa A, Szmit-Domagalska J, Jackowski T, Safranow K, Petriczko E Int J Environ Res Public Health. 2022; 19(18).

PMID: 36141955 PMC: 9517116. DOI: 10.3390/ijerph191811686.

Fitness Levels and Gender Are Related With the Response of Plasma Adipokines and Inflammatory Cytokines in Prepubertal Children.

Llorente-Cantarero F, Aguilera C, Perez-Navero J, Gil A, Benitez-Sillero J, Gil-Campos M Front Nutr. 2022; 9:883871.

PMID: 35529460 PMC: 9069158. DOI: 10.3389/fnut.2022.883871.

Is Office Blood Pressure Measurement Reliable in Obese Adolescents?.

Tepe D, Yilmaz S Diabetes Metab Syndr Obes. 2021; 14:3809-3817.

PMID: 34511954 PMC: 8421040. DOI: 10.2147/DMSO.S329273.

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