In Vitro Synergistic Activities of Antimicrobial Peptide Brevinin-2CE with Five Kinds of Antibiotics Against Multidrug-resistant Clinical Isolates

Overview

Journal Curr Microbiol

Specialty Microbiology

Date 2014 Jan 30

PMID 24474334

Citations 19

Authors

Yuan Zhang

Yukun Liu

Yan Sun

Qingmei Liu

Xiaoyan Wang

Zhi Li

Jie Hao

Affiliations

Soon will be listed here.

Abstract

Antimicrobial peptides are the promising candidates for withstanding multidrug-resistant bacteria (MDRB) which were caused by the misuse and extensive use of antibiotics. In this research, in vitro activities of one antimicrobial cationic peptide, brevinin-2CE alone and in combination with five kinds of antibiotics were assessed against clinical isolates of extended-spectrum β-lactamase-producing Escherichia coli and methicillin-resistant Staphylococcus aureus. The results showed that most of the combination groups had synergistic effects. Also, it was obvious that brevinin-2CE had more rapid and severe action on the tested MDRBs which demonstrated that brevinin-2CE and the antibiotics had different antimicrobial mechanisms. Thus, it was presumed that the antimicrobial peptides destroyed the bacterial cells via pore formation mechanisms which lead to the increasing of membrane permeability; and then the other compounds like antibiotics might enter into the cells and accomplish the antimicrobial activities more rapidly and efficiently.

Citing Articles

Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic-Antimicrobial Peptide Conjugates.

Bellucci M, Romani C, Sani M, Volonterio A Antibiotics (Basel). 2024; 13(8).

PMID: 39200083 PMC: 11352213. DOI: 10.3390/antibiotics13080783.

Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of to antimicrobial peptide Brevinin-2CE.

Bing C, Mengjuan A, Xinyu M, Chixin Z, Xinyao T, Yan S Future Microbiol. 2024; 19(9):771-782.

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Complementary Activities of Host Defence Peptides and Antibiotics in Combating Antimicrobial Resistant Bacteria.

Lennard P, Hiemstra P, Nibbering P Antibiotics (Basel). 2023; 12(10).

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HAZ, a novel peptide with broad-spectrum antibacterial activity.

Alsaggar M, Al-Hazabreh M, Al Tall Y, Al-Tarawneh A, Darweesh R, Masadeh M Saudi Pharm J. 2022; 30(11):1652-1658.

PMID: 36465844 PMC: 9715947. DOI: 10.1016/j.jsps.2022.09.009.

Truncated analog Brevinin2-CE-N26V5K: Revelation the Augmentation of Antimicrobial Activity.

Zhao Y, Wang X, Sun Y, Li Z, Liu T, Liu Q World J Microbiol Biotechnol. 2022; 38(9):162.

PMID: 35834028 DOI: 10.1007/s11274-022-03333-1.

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