Dental Manifestations of Patient with Vitamin D-resistant Rickets

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2014 Jan 30

PMID 24473729

Citations 15

Authors

Andreia Pereira Souza

Tatiana Yuriko Kobayashi

Natalino Lourenco Neto

Salete Moura Bonifacio Silva

Maria Aparecida Andrade Moreira Machado

Thais Marchini Oliveira

Affiliations

Soon will be listed here.

Abstract

Patients with Vitamin D-resistant rickets have abnormal tooth morphology such as thin globular dentin and enlarged pulp horns that extend into the dentino-enamel junction. Invasion of the pulp by microorganisms and toxins is inevitable. The increased fibrotic content of the pulp, together with a reduced number of odontoblasts, decreases the response to pulp infection. The most important oral findings are characterized by spontaneous gingival and dental abscesses occuring without history of trauma or caries. Radiographic examinations revealed large pulp chambers, short roots, poorly defined lamina dura and hypoplastic alveolar ridge. These dental abscesses are common and therefore the extraction and pulpectomy are the treatment of choice. The purpose of this article is to report a case of Vitamin D-resistant rickets in a 5 year-old boy, describing the dental findings and the treatment to be performed in these cases.

Citing Articles

Dental manifestations and treatment of hypophosphatemic rickets: A case report and review of literature.

Jin X, Xu Y, Liu W, Shi Z, Sun Y, Pan X BDJ Open. 2023; 9(1):2.

PMID: 36717535 PMC: 9886973. DOI: 10.1038/s41405-023-00129-9.

Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.

Altaie A, Venkatachalam T, Samaranayake L, Soliman S, Hamoudi R Front Immunol. 2021; 12:707267.

PMID: 34539639 PMC: 8446658. DOI: 10.3389/fimmu.2021.707267.

Vitamin D, pregnancy and caries in children in the INMA-Asturias birth cohort.

Suarez-Calleja C, Aza-Morera J, Iglesias-Cabo T, Tardon A BMC Pediatr. 2021; 21(1):380.

PMID: 34479530 PMC: 8414781. DOI: 10.1186/s12887-021-02857-z.

Osteodystrophies of jaws.

Santana N, Mehazabin S, Sangeetha K, Kumari M J Oral Maxillofac Pathol. 2021; 24(2):405.

PMID: 33456267 PMC: 7802870. DOI: 10.4103/jomfp.JOMFP_225_19.

Oral manifestations of lamellar ichthyosis in association with rickets.

Tewari N, Mathur V, Tamchos R, Rahul M BMJ Case Rep. 2020; 13(7).

PMID: 32641302 PMC: 7348650. DOI: 10.1136/bcr-2020-235008.

References

Chaussain-Miller C, Sinding C, Wolikow M, Lasfargues J, Godeau G, Garabedian M . Dental abnormalities in patients with familial hypophosphatemic vitamin D-resistant rickets: prevention by early treatment with 1-hydroxyvitamin D. J Pediatr. 2003; 142(3):324-31. DOI: 10.1067/mpd.2003.119. View

Beltes C, Zachou E . Endodontic management in a patient with vitamin D-resistant Rickets. J Endod. 2012; 38(2):255-8. DOI: 10.1016/j.joen.2011.10.025. View

Goodman J, Gelbier M, Bennett J, WINTER G . Dental problems associated with hypophosphataemic vitamin D resistant rickets. Int J Paediatr Dent. 1998; 8(1):19-28. DOI: 10.1046/j.1365-263x.1998.00059.x. View

Carpenter T . New perspectives on the biology and treatment of X-linked hypophosphatemic rickets. Pediatr Clin North Am. 1997; 44(2):443-66. DOI: 10.1016/s0031-3955(05)70485-5. View

Murayama T, Iwatsubo R, Akiyama S, Amano A, Morisaki I . Familial hypophosphatemic vitamin D-resistant rickets: dental findings and histologic study of teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 90(3):310-6. DOI: 10.1067/moe.2000.107522. View

Seow W . Diagnosis and management of unusual dental abscesses in children. Aust Dent J. 2003; 48(3):156-68. DOI: 10.1111/j.1834-7819.2003.tb00026.x. View

Zambrano M, Nikitakis N, Sanchez-Quevedo M, Sauk J, Sedano H, Rivera H . Oral and dental manifestations of vitamin D-dependent rickets type I: report of a pediatric case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95(6):705-9. DOI: 10.1067/moe.2003.116. View

Chaussain-Miller C, Sinding C, Septier D, Wolikow M, Goldberg M, Garabedian M . Dentin structure in familial hypophosphatemic rickets: benefits of vitamin D and phosphate treatment. Oral Dis. 2007; 13(5):482-9. DOI: 10.1111/j.1601-0825.2006.01326.x. View

Ozkan S, Ucok Z, Alagol F . Dental manifestations of familial hypophosphatemic vitamin-D-resistant rickets: report of case. ASDC J Dent Child. 1984; 51(6):448-50. View

10.

Seow W, Latham S . The spectrum of dental manifestations in vitamin D-resistant rickets: implications for management. Pediatr Dent. 1986; 8(3):245-50. View

11.

Breen G . Prophylactic dental treatment for a patient with vitamin D-resistant rickets: report of case. ASDC J Dent Child. 1986; 53(1):38-43. View

12.

Hillmann G, Geurtsen W . Pathohistology of undecalcified primary teeth in vitamin D-resistant rickets: review and report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996; 82(2):218-24. DOI: 10.1016/s1079-2104(96)80260-5. View

13.

Rabbani A, Rahmani P, Ziaee V, Ghodoosi S . Dental problems in hypophosphatemic rickets, a cross sectional study. Iran J Pediatr. 2013; 22(4):531-4. PMC: 3533156. View

14.

Yasufuku Y, Kohno N, Tsutsumi N, Ooshima T, Sobue S, Murakami Y . Dental management of familial hypophosphatemic vitamin D-resistant rickets: report of case. ASDC J Dent Child. 1983; 50(4):300-4. View

15.

Shroff D, McWhorter A, Seale N . Evaluation of aggressive pulp therapy in a population of vitamin D-resistant rickets patients: a follow-up of 4 cases. Pediatr Dent. 2002; 24(4):347-9. View

16.

Andersen M, Beck-Nielsen S, Haubek D, Hintze H, Gjorup H, Poulsen S . Periapical and endodontic status of permanent teeth in patients with hypophosphatemic rickets. J Oral Rehabil. 2011; 39(2):144-50. DOI: 10.1111/j.1365-2842.2011.02250.x. View