Reliability of Triclosan Measures in Repeated Urine Samples from Norwegian Pregnant Women

Overview

Journal J Expo Sci Environ Epidemiol

Specialties Environmental Health
Public Health

Date 2014 Jan 30

PMID 24472755

Citations 27

Authors

Randi J Bertelsen

Stephanie M Engel

Todd A Jusko

Antonia M Calafat

Jane A Hoppin

Stephanie J London

Merete Eggesbo

Heidi Aase

Pal Zeiner

Ted Reichborn-Kjennerud

Gun P Knudsen

Virginia T Guidry

Matthew P Longnecker

Affiliations

Soon will be listed here.

Abstract

Triclosan (TCS) is a synthetic antibacterial chemical that is used in personal care products and is measurable in urine. Urinary TCS has been associated with allergy in children in Norway and the United States. A reasonable degree of temporal reliability of TCS urinary concentrations has been reported among US children as well as for Puerto Rican pregnant women. We examined the reliability of TCS measures in urine among Norwegian pregnant women. TCS was measured in spot urine samples collected in gestational weeks 17, 23, and 29 from 45 women in The Norwegian Mother and Child Cohort Study (MoBa) enrolled in 2007 and 2008. Spearman's rank correlation coefficient (rs) and intraclass correlation coefficient (ICC) statistics were calculated. Fifty-six percent of the 45 women had a least one sample with a value above the method limit of detection (2.3 μg/l). The correlation coefficients were 0.61 for TCS concentrations at 17 and 23 weeks and 0.49 for concentrations at 17 and 29 weeks. For the three time points, the ICC was 0.49. The reliability of TCS concentrations in repeated urine samples from pregnant Norwegian women was reasonably good, suggesting a single urine sample can adequately represent TCS exposure during pregnancy.

Citing Articles

Monitoring human exposure to four parabens and triclosan: comparing silicone wristbands with spot urine samples as predictors of internal dose.

Levasseur J, Hoffman K, Zhang S, Cooper E, Stapleton H J Expo Sci Environ Epidemiol. 2024; 34(4):670-678.

PMID: 38704446 PMC: 11303247. DOI: 10.1038/s41370-024-00663-0.

Urinary phenol concentrations and fecundability and early pregnancy loss.

Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N Hum Reprod. 2022; 38(1):139-155.

PMID: 36346334 PMC: 10089295. DOI: 10.1093/humrep/deac230.

Effect of Maternal Triclosan Exposure on Neonatal Thyroid-Stimulating Hormone Levels: A Cross-Sectional Study.

Attarian E, Ebrahimpour K, Maracy M, Daniali S, Shoshtari-Yeganeh B, Moazeni M J Environ Public Health. 2022; 2022:3082304.

PMID: 36213011 PMC: 9534696. DOI: 10.1155/2022/3082304.

Exposure to Antibacterial Chemicals Is Associated With Altered Composition of Oral Microbiome.

Vindenes H, Lin H, Shigdel R, Ringel-Kulka T, Real F, Svanes C Front Microbiol. 2022; 13:790496.

PMID: 35572708 PMC: 9096491. DOI: 10.3389/fmicb.2022.790496.

Exposure to environmental phenols and parabens, and relation to body mass index, eczema and respiratory outcomes in the Norwegian RHINESSA study.

Vindenes H, Svanes C, Lygre S, Real F, Ringel-Kulka T, Bertelsen R Environ Health. 2021; 20(1):81.

PMID: 34256787 PMC: 8278607. DOI: 10.1186/s12940-021-00767-2.

References

Ye X, Zhou X, Hennings R, Kramer J, Calafat A . Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge. Environ Health Perspect. 2013; 121(3):283-6. PMC: 3621191. DOI: 10.1289/ehp.1206093. View

Lassen T, Frederiksen H, Jensen T, Petersen J, Main K, Skakkebaek N . Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples. Environ Res. 2013; 126:164-70. DOI: 10.1016/j.envres.2013.07.001. View

Magnus P, Irgens L, Haug K, Nystad W, Skjaerven R, Stoltenberg C . Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol. 2006; 35(5):1146-50. DOI: 10.1093/ije/dyl170. View

Savage J, Matsui E, Wood R, Keet C . Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. J Allergy Clin Immunol. 2012; 130(2):453-60.e7. PMC: 3720124. DOI: 10.1016/j.jaci.2012.05.006. View

Ye X, Kuklenyik Z, Needham L, Calafat A . Automated on-line column-switching HPLC-MS/MS method with peak focusing for the determination of nine environmental phenols in urine. Anal Chem. 2005; 77(16):5407-13. DOI: 10.1021/ac050390d. View

. Measurement of near zero concentration: recording and reporting results that fall close to or below the detection limit. Analyst. 2001; 126(2):256-9. DOI: 10.1039/b009590g. View

Calafat A, Ye X, Wong L, Reidy J, Needham L . Urinary concentrations of triclosan in the U.S. population: 2003-2004. Environ Health Perspect. 2008; 116(3):303-7. PMC: 2265044. DOI: 10.1289/ehp.10768. View

Irgens L . The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand. 2000; 79(6):435-9. View

Bertelsen R, Longnecker M, Lovik M, Calafat A, Carlsen K, London S . Triclosan exposure and allergic sensitization in Norwegian children. Allergy. 2012; 68(1):84-91. PMC: 3515701. DOI: 10.1111/all.12058. View

10.

Nie L, Chu H, Liu C, Cole S, Vexler A, Schisterman E . Linear regression with an independent variable subject to a detection limit. Epidemiology. 2011; 21 Suppl 4:S17-24. PMC: 3265361. DOI: 10.1097/EDE.0b013e3181ce97d8. View

11.

Sandborgh-Englund G, Adolfsson-Erici M, Odham G, Ekstrand J . Pharmacokinetics of triclosan following oral ingestion in humans. J Toxicol Environ Health A. 2006; 69(20):1861-73. DOI: 10.1080/15287390600631706. View

12.

Meeker J, Cantonwine D, Rivera-GonzAlez L, Ferguson K, Mukherjee B, Calafat A . Distribution, variability, and predictors of urinary concentrations of phenols and parabens among pregnant women in Puerto Rico. Environ Sci Technol. 2013; 47(7):3439-47. PMC: 3638245. DOI: 10.1021/es400510g. View

13.

Teitelbaum S, Britton J, Calafat A, Ye X, Silva M, REIDY J . Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res. 2007; 106(2):257-69. DOI: 10.1016/j.envres.2007.09.010. View

14.

Philippat C, Wolff M, Calafat A, Ye X, Bausell R, Meadows M . Prenatal exposure to environmental phenols: concentrations in amniotic fluid and variability in urinary concentrations during pregnancy. Environ Health Perspect. 2013; 121(10):1225-31. PMC: 3801458. DOI: 10.1289/ehp.1206335. View

15.

Longnecker M, Harbak K, Kissling G, Hoppin J, Eggesbo M, Jusko T . The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling. Environ Res. 2013; 126:211-4. PMC: 3805685. DOI: 10.1016/j.envres.2013.07.002. View

16.

Barr D, Wilder L, Caudill S, Gonzalez A, Needham L, Pirkle J . Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 2005; 113(2):192-200. PMC: 1277864. DOI: 10.1289/ehp.7337. View