Coupling of Tyrosine Deprotonation and Axial Ligand Exchange in Nitrocytochrome C

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2014 Jan 29

PMID 24471160

Citations 3

Authors

Daiana A Capdevila

Damian Alvarez-Paggi

Maria A Castro

Veronica Tortora

Veronica Demicheli

Dario A Estrin

Rafael Radi

Daniel H Murgida

Affiliations

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Abstract

Here we report a spectroscopic, electrochemical and computational study of cytochrome c showing that nitration of Tyr74 induces Tyr deprotonation, which is coupled to Met/Lys axial ligand exchange, and results in concomitant gain of peroxidatic activity at physiological pH.

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