Association Between HTLV-I Infection with Chronic Lupoid Leishmaniasis

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2014 Jan 29

PMID 24470878

Citations 5

Authors

Fakhrozaman Pezeshkpoor

Seyed Abdol Rahim Rezaei

Abbas Shirdel

Mohammad Khajedaluee

Mansoreh Alizadeh

Mohammad Javad Yazdanpanah

Affiliations

Soon will be listed here.

Abstract

Objective(s): One of the different types of skin leishmaniasis is the Chronic Lupoid Leishmaniasis (CLL), which is caused by abnormal immune response. On the other hand, HTLV-I has been known to exist in some infectious diseases. Human T cell lymphotropic virus type1 (HTLV-I) and cutanous leishmaniasis exists endemically in Mashhad. The objective of this study was to evaluate the prevalence of HTLV-I in CLL patients.

Materials And Methods: This cross sectional study involved 51 CLL patients admitted to cutaneous leishmaniasis clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. The blood samples were examined for serology tests through ELISA method.

Results: The results of the experiments for evaluating the existence of HTLV-I in 51 patients under study in this research were proved to be negative.

Conclusion: According to this pilot study, the distribution of HTLV-I in CLL patients is not higher than normal population.

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References

Lenis A, Blank A, Valderrama L, Saravia N . Relationship between the human T-lymphotropic virus type 1 infection and clinical manifestations of tegumentary leishmaniasis in the Colombian Pacific Coast. Mem Inst Oswaldo Cruz. 1999; 94(1):19-20. DOI: 10.1590/s0074-02761999000100007. View

Ajdary S, Alimohammadian M, Eslami M, Kemp K, Kharazmi A . Comparison of the immune profile of nonhealing cutaneous Leishmaniasis patients with those with active lesions and those who have recovered from infection. Infect Immun. 2000; 68(4):1760-4. PMC: 97345. DOI: 10.1128/IAI.68.4.1760-1764.2000. View

Kuroda Y, Takashima H . Impairment of cell-mediated immune responses in HTLV-I-associated myelopathy. J Neurol Sci. 1990; 100(1-2):211-6. DOI: 10.1016/0022-510x(90)90035-l. View

Oumeish O . Cutaneous leishmaniasis: a historical perspective. Clin Dermatol. 1999; 17(3):249-54. View

Rafatpanah H, Hedayati-Moghaddam M, Fathimoghadam F, Bidkhori H, Shamsian S, Ahmadi S . High prevalence of HTLV-I infection in Mashhad, Northeast Iran: a population-based seroepidemiology survey. J Clin Virol. 2011; 52(3):172-6. DOI: 10.1016/j.jcv.2011.07.004. View

Meymandi S, Dabiri S, Shamsi-Meymandi M, Nikpour H, Kharazmi A . Immunophenotypic pattern and cytokine profiles of dry type cutaneous leishmaniasis. Arch Iran Med. 2009; 12(4):371-6. View

Nakada K, Yamaguchi K, Furugen S, Nakasone T, Nakasone K, Oshiro Y . Monoclonal integration of HTLV-I proviral DNA in patients with strongyloidiasis. Int J Cancer. 1987; 40(2):145-8. DOI: 10.1002/ijc.2910400203. View

Lenzi M, Cuzzi-Maya T, Oliveira A, Andrada-Serpa M, Araujo A . Dermatological findings of human T lymphotropic virus type 1 (HTLV-I)-associated myelopathy/tropical spastic paraparesis. Clin Infect Dis. 2003; 36(4):507-13. DOI: 10.1086/367572. View

Stefanidou M, Antoniou M, Koutsopoulos A, Neofytou Y, Krasagakis K, Kruger-Krasagakis S . A rare case of leishmaniasis recidiva cutis evolving for 31 years caused by Leishmania tropica. Int J Dermatol. 2008; 47(6):588-9. DOI: 10.1111/j.1365-4632.2008.03240.x. View

10.

Goncalves D, Guedes A, Proietti A, Martins M, Proietti F, Lambertucci J . Dermatologic lesions in asymptomatic blood donors seropositive for human T cell lymphotropic virus type-1. Am J Trop Med Hyg. 2003; 68(5):562-5. DOI: 10.4269/ajtmh.2003.68.562. View

11.

Asilian A, Iraji F, Hedaiti H, Siadat A, Enshaieh S . Carbon dioxide laser for the treatment of lupoid cutaneous leishmaniasis (LCL): a case series of 24 patients. Dermatol Online J. 2006; 12(2):3. View