Thyroid Disorders Associated with Alopecia Areata in Egyptian Patients

Overview

Journal Indian J Dermatol

Specialty Dermatology

Date 2014 Jan 29

PMID 24470660

Citations 12

Authors

Ola A Bakry

Mohamed A Basha

Maather K El Shafiee

Wafaa A Shehata

Affiliations

Soon will be listed here.

Abstract

Context: Alopecia areata (AA) is a common form of localized, non-scarring hair loss. The etiopathogenesis of the disease is still unclear, but the role of autoimmunity is strongly suggested. AA is commonly associated with various autoimmune disorders; the most frequent among them is autoimmune thyroid disorders.

Aim: To determine whether AA is associated with thyroid autoimmunity or thyroid function abnormalities in Egyptian patients.

Materials And Methods: Fifty subjects with AA (37 males and 13 females) without clinical evidence of thyroid disorders were selected from Dermatology Outpatient Clinic, Menoufiya University Hospital, Menoufiya Governorate, Egypt, during the period from June 2009 to February 2010. They were divided into 3 groups according to severity of AA. Fifty age and sex-matched healthy volunteers (35 males and 15 females) were selected as a control group. Every case and control were subjected to history taking, complete general and dermatological examination. Venous blood samples were taken from cases and controls after taking their consents for measurement of thyroid stimulating hormone (TSH), free T3, freeT4 and detection of Anti-thyroglobulin Antibody (Tg-Ab) and Anti-thyroid Peroxidase Antibody (TPO-Ab).

Results: Subclinical hypothyroidism was detected in 16% of cases. There were statistically significant differences between cases and controls regarding levels of TSH, free T3 and free T4. There were significant differences between cases and controls regarding the presence of Tg-Ab and TPO-Ab.

Conclusions: Every patient with AA should be screened for thyroid functions and presence of thyroid autoantibodies even in absence of clinical manifestations suggestive of thyroid affection.

Citing Articles

Immune-Molecular Link between Thyroid and Skin Autoimmune Diseases: A Narrative Review.

Carlucci P, Spataro F, Cristallo M, Di Gioacchino M, Nettis E, Gangemi S J Clin Med. 2024; 13(18).

PMID: 39337081 PMC: 11433455. DOI: 10.3390/jcm13185594.

Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction Causality Analysis Study.

Zhao Y, Guo F, Guo M Skin Res Technol. 2024; 30(10):e70063.

PMID: 39331482 PMC: 11430218. DOI: 10.1111/srt.70063.

The genetic link between thyroid dysfunction and alopecia areata: a bidirectional two-sample Mendelian randomization study.

Gao L, Li W, Song Q, Gao H, Chen M Front Endocrinol (Lausanne). 2024; 15:1440941.

PMID: 39205687 PMC: 11349512. DOI: 10.3389/fendo.2024.1440941.

Relationship of Hypothyroidism with Alopecia Areata and Androgenetic Alopecia: Insights from a Two-Sample Mendelian Randomization Study.

Zhang G, Huang X, Li H, Gong H, Zhou Y, Liu F Clin Cosmet Investig Dermatol. 2024; 17:1865-1874.

PMID: 39188772 PMC: 11346484. DOI: 10.2147/CCID.S474168.

Association between non-scarring alopecia and hypothyroidism: a bidirectional two-sample Mendelian randomization study.

Yang J, Zhu Z, Zhang C, Guo Y, Wang G, Fu M Front Endocrinol (Lausanne). 2024; 15:1356832.

PMID: 38562416 PMC: 10982309. DOI: 10.3389/fendo.2024.1356832.

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