Effects of Gustatory Nerve Transection And/or Ovariectomy on Oral Capsaicin Avoidance in Rats

Overview

Journal Pain

Specialties Neurology
Psychiatry

Date 2014 Jan 29

PMID 24468031

Citations 7

Authors

Yves Boucher

Christopher T Simons

Mirela Iodi Carstens

E Carstens

Affiliations

Soon will be listed here.

Abstract

The incidence of chronic oral pain such as burning mouth syndrome is greater in peri-menopausal females, and was postulated to be associated with gustatory nerve damage. We investigated whether bilateral transection of the chorda tympani, with or without accompanying ovariectomy, affected oral capsaicin avoidance in rats. Female rats had restricted access to 2 bottles, 1 bottle containing capsaicin (concentration range: 0.33-33 μM/L) and the other vehicle. Percent volume of capsaicin consumption and lick counts were measured. The concentration series was tested before and 0.5, 3, 6, 9, and 12 months after the following surgical procedures: (a) bilateral transection of the chorda tympani (CTx); (b) ovariectomy (OVx); (3) CTx plus OVx; or (4) sham CT surgery. Before surgery there was a concentration-dependent decrease in licks and volume of capsaicin consumed, with a threshold between 0.1 and 0.3 ppm. The majority of drink licks occurred during the first 9 minutes of access. Over the 12-month test period, the CTx group did not exhibit reduced capsaicin consumption, and consumed significantly more capsaicin at 6 and 9 months postsurgery. Rats in the OVx group consistently consumed significantly less capsaicin and exhibited significantly higher counts of capsaicin-evoked Fos-like immunoreactivity in the dorsomedial trigeminal subnucleus caudalis (Vc) compared to all other treatment groups. That CTx, with or without OVx, did not enhance capsaicin avoidance indicates that damage to the gustatory system does not disinhibit trigeminal nociceptive transmission.

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References

Anseloni V, Ren K, Dubner R, Ennis M . A brainstem substrate for analgesia elicited by intraoral sucrose. Neuroscience. 2005; 133(1):231-43. DOI: 10.1016/j.neuroscience.2005.01.055. View

Fillingim R, Ness T . Sex-related hormonal influences on pain and analgesic responses. Neurosci Biobehav Rev. 2000; 24(4):485-501. DOI: 10.1016/s0149-7634(00)00017-8. View

Lawless H, Stevens D . Effects of oral chemical irritation on taste. Physiol Behav. 1984; 32(6):995-8. DOI: 10.1016/0031-9384(84)90291-9. View

Karrer T, Bartoshuk L . Effects of capsaicin desensitization on taste in humans. Physiol Behav. 1995; 57(3):421-9. DOI: 10.1016/0031-9384(94)e0076-g. View

Femiano F, Gombos F, Esposito V, Nunziata M, Scully C . Burning mouth syndrome (BMS): evaluation of thyroid and taste. Med Oral Patol Oral Cir Bucal. 2006; 11(1):E22-5. View

Blass E, Shide D . Some comparisons among the calming and pain-relieving effects of sucrose, glucose, fructose and lactose in infant rats. Chem Senses. 1994; 19(3):239-49. DOI: 10.1093/chemse/19.3.239. View

Halpern B, Nelson L . BULBAR GUSTATORY RESPONSES TO ANTERIOR AND TO POSTERIOR TONGUE STIMULATION IN THE RAT. Am J Physiol. 1965; 209:105-10. DOI: 10.1152/ajplegacy.1965.209.1.105. View

Gaumond I, Arsenault P, Marchand S . Specificity of female and male sex hormones on excitatory and inhibitory phases of formalin-induced nociceptive responses. Brain Res. 2005; 1052(1):105-11. DOI: 10.1016/j.brainres.2005.06.011. View

Gaumond I, Arsenault P, Marchand S . The role of sex hormones on formalin-induced nociceptive responses. Brain Res. 2002; 958(1):139-45. DOI: 10.1016/s0006-8993(02)03661-2. View

10.

Blass E, Watt L . Suckling- and sucrose-induced analgesia in human newborns. Pain. 1999; 83(3):611-623. DOI: 10.1016/S0304-3959(99)00166-9. View

11.

Lamey P, Freeman R, Eddie S, Pankhurst C, Rees T . Vulnerability and presenting symptoms in burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 99(1):48-54. DOI: 10.1016/j.tripleo.2004.01.021. View

12.

Craft R, Mogil J, Aloisi A . Sex differences in pain and analgesia: the role of gonadal hormones. Eur J Pain. 2004; 8(5):397-411. DOI: 10.1016/j.ejpain.2004.01.003. View

13.

Boucher Y, Felizardo R, Klein A, Carstens M, Carstens E . Gustatory modulation of the responses of trigeminal subnucleus caudalis neurons to noxious stimulation of the tongue in rats. Eur J Neurosci. 2013; 38(6):2812-22. PMC: 4591004. DOI: 10.1111/ejn.12282. View

14.

Bartoshuk L . Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem Senses. 2000; 25(4):447-60. DOI: 10.1093/chemse/25.4.447. View

15.

Simons C, Gogineni A, Carstens M, Carstens E . Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors. Brain Res. 2002; 945(1):139-43. DOI: 10.1016/s0006-8993(02)02913-x. View

16.

Roane D, Martin R . Continuous sucrose feeding decreases pain threshold and increases morphine potency. Pharmacol Biochem Behav. 1990; 35(1):225-9. DOI: 10.1016/0091-3057(90)90230-f. View

17.

Boucher Y, Carstens M, Sawyer C, Zanotto K, Merrill A, Carstens E . Capsaicin avoidance as a measure of chemical hyperalgesia in orofacial nerve injury models. Neurosci Lett. 2013; 543:37-41. PMC: 3649860. DOI: 10.1016/j.neulet.2013.02.060. View

18.

Ceccarelli I, Fiorenzani P, Massafra C, Aloisi A . Long-term ovariectomy changes formalin-induced licking in female rats: the role of estrogens. Reprod Biol Endocrinol. 2003; 1:24. PMC: 151796. DOI: 10.1186/1477-7827-1-24. View

19.

Woda A, Dao T, Gremeau-Richard C . Steroid dysregulation and stomatodynia (burning mouth syndrome). J Orofac Pain. 2009; 23(3):202-10. View

20.

Grushka M . Clinical features of burning mouth syndrome. Oral Surg Oral Med Oral Pathol. 1987; 63(1):30-6. DOI: 10.1016/0030-4220(87)90336-7. View