Mathematical Modeling on Bacterial Resistance to Multiple Antibiotics Caused by Spontaneous Mutations

Overview

Journal Biosystems

Specialty Biology

Date 2014 Jan 29

PMID 24467935

Citations 8

Authors

Eduardo Ibarguen-Mondragon

Saulo Mosquera

Miller Ceron

Edith Mariela Burbano-Rosero

Sandra P Hidalgo-Bonilla

Lourdes Esteva

Jhoana P Romero-Leiton

Affiliations

Soon will be listed here.

Abstract

We formulate a mathematical model that describes the population dynamics of bacteria exposed to multiple antibiotics simultaneously, assuming that acquisition of resistance is through mutations due to antibiotic exposure. Qualitative analysis reveals the existence of a free-bacteria equilibrium, resistant-bacteria equilibrium and an endemic equilibrium where both bacteria coexist.

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