Reduced Fetal Telomere Length in Gestational Diabetes

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jan 28

PMID 24465936

Citations 33

Authors

Jian Xu

Junyi Ye

Yanting Wu

Hong Zhang

Qiong Luo

Cong Han

Xiaoqun Ye

Hanzhi Wang

Jing He

Hefeng Huang

Yun Liu

Minyue Dong

Affiliations

Soon will be listed here.

Abstract

Gestational diabetes mellitus (GDM) is an important complication of pregnancy that poses significant threats to women and their offspring. Telomere length shortens as cellular damage increases and is associated with metabolic diseases. Telomere length in fetal leucocytes was determined in 82 infants of women with GDM (N = 82) and 65 normal pregnant women (N = 65). Women with preeclampsia (N = 45) and gestational hypertension (N = 23) were also studied. In the GDM group, telomere length was significantly shorter than normal pregnancy (P = 0.028), but there were no significant differences in fetal telomere length between preeclampsia and normal pregnancy (P = 0.841) and between gestational hypertension and normal pregnancy (P = 0.561). Regression analysis revealed that fetal telomere length was significantly associated with intrauterine exposure to GDM (P = 0.027 after adjustment for maternal age, gestational age at delivery, birth weight and fetal gender). Shortened telomere length may increase the risk of metabolic diseases in adulthood of GDM offspring.

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References

Serrano A, Andres V . Telomeres and cardiovascular disease: does size matter?. Circ Res. 2004; 94(5):575-84. DOI: 10.1161/01.RES.0000122141.18795.9C. View

Tastekin A, Ors R, Demircan B, Saricam Z, Ingec M, Akcay F . Oxidative stress in infants born to preeclamptic mothers. Pediatr Int. 2005; 47(6):658-62. DOI: 10.1111/j.1442-200x.2005.02146.x. View

Sahin E, Colla S, Liesa M, Moslehi J, Muller F, Guo M . Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011; 470(7334):359-65. PMC: 3741661. DOI: 10.1038/nature09787. View

Kinalski M, Sledziewski A, Telejko B, Kowalska I, Kretowski A, Zarzycki W . Lipid peroxidation, antioxidant defence and acid-base status in cord blood at birth: the influence of diabetes. Horm Metab Res. 2001; 33(4):227-31. DOI: 10.1055/s-2001-14953. View

Biron-Shental T, Sukenik-Halevy R, Sharon Y, Goldberg-Bittman L, Kidron D, Fejgin M . Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol. 2010; 202(4):381.e1-7. DOI: 10.1016/j.ajog.2010.01.036. View

Blackburn E . Structure and function of telomeres. Nature. 1991; 350(6319):569-73. DOI: 10.1038/350569a0. View

. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol. 2005; 99(1):159-67. DOI: 10.1016/s0029-7844(01)01747-1. View

Howlader M, Parveen S, Tamanna S, Khan T, Begum F . Oxidative stress and antioxidant status in neonates born to pre-eclamptic mother. J Trop Pediatr. 2009; 55(6):363-7. DOI: 10.1093/tropej/fmp025. View

Okuda K, Bardeguez A, Gardner J, Rodriguez P, Ganesh V, Kimura M . Telomere length in the newborn. Pediatr Res. 2002; 52(3):377-81. DOI: 10.1203/00006450-200209000-00012. View

10.

Geelhoed J, Fraser A, Tilling K, Benfield L, Davey Smith G, Sattar N . Preeclampsia and gestational hypertension are associated with childhood blood pressure independently of family adiposity measures: the Avon Longitudinal Study of Parents and Children. Circulation. 2010; 122(12):1192-9. PMC: 5321267. DOI: 10.1161/CIRCULATIONAHA.110.936674. View

11.

Frenck Jr R, Blackburn E, Shannon K . The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A. 1998; 95(10):5607-10. PMC: 20425. DOI: 10.1073/pnas.95.10.5607. View

12.

Sobki S, Al-Senaidy A, Al-Shammari T, Inam S, Al-Gwiser A, Bukhari S . Impact of gestational diabetes on lipid profiling and indices of oxidative stress in maternal and cord plasma. Saudi Med J. 2004; 25(7):876-80. View

13.

Steegers E, von Dadelszen P, Duvekot J, Pijnenborg R . Pre-eclampsia. Lancet. 2010; 376(9741):631-44. DOI: 10.1016/S0140-6736(10)60279-6. View

14.

Suhail M, Suhail S, Gupta B, Bharat V . Malondialdehyde and Antioxidant Enzymes in Maternal and Cord Blood, and their Correlation in Normotensive and Preeclamptic Women. J Clin Med Res. 2012; 1(3):150-7. PMC: 3318878. DOI: 10.4021/jocmr2009.07.1252. View

15.

Blackburn E . Telomere states and cell fates. Nature. 2000; 408(6808):53-6. DOI: 10.1038/35040500. View

16.

Kurepa D, Pramanik A, Kakkilaya V, Caldito G, Groome L, Bocchini J . Elevated acetoacetate and monocyte chemotactic protein-1 levels in cord blood of infants of diabetic mothers. Neonatology. 2012; 102(3):163-8. PMC: 3557819. DOI: 10.1159/000339286. View

17.

Lawlor D, Fraser A, Lindsay R, Ness A, Dabelea D, Catalano P . Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia. 2009; 53(1):89-97. DOI: 10.1007/s00125-009-1560-z. View

18.

Demerath E, Cameron N, Gillman M, Towne B, Siervogel R . Telomeres and telomerase in the fetal origins of cardiovascular disease: a review. Hum Biol. 2004; 76(1):127-46. PMC: 2801408. DOI: 10.1353/hub.2004.0018. View

19.

Entringer S, Epel E, Kumsta R, Lin J, Hellhammer D, Blackburn E . Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci U S A. 2011; 108(33):E513-8. PMC: 3158153. DOI: 10.1073/pnas.1107759108. View

20.

Metzger B, Gabbe S, Persson B, Buchanan T, Catalano P, Damm P . International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010; 33(3):676-82. PMC: 2827530. DOI: 10.2337/dc09-1848. View