Crosstalk Between Insulin and Toll-like Receptor Signaling Pathways in the Central Nervous System

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2014 Jan 28

PMID 24464263

Citations 10

Authors

Fatemeh Hemmati

Rasoul Ghasemi

Norlinah Mohamed Ibrahim

Leila Dargahi

Zahurin Mohamed

Azman Ali Raymond

Abolhassan Ahmadiani

Affiliations

Soon will be listed here.

Abstract

Neuroinflammation is known as a key player in a variety of neurodegenerative and/or neurological diseases. Brain Toll-like receptors (TLRs) are leading elements in the initiation and progression of neuroinflammation and the development of different neuronal diseases. Furthermore, TLR activation is one of the most important elements in the induction of insulin resistance in different organs such as the central nervous system. Involvement of insulin signaling dysregulation and insulin resistance are also shown to contribute to the pathology of neurological diseases. Considering the important roles of TLRs in neuroinflammation and central insulin resistance and the effects of these processes in the initiation and progression of neurodegenerative and neurological diseases, here we are going to review current knowledge about the potential crosstalk between TLRs and insulin signaling pathways in neuroinflammatory disorders of the central nervous system.

Citing Articles

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