A Review of the Haematopoietic Stem Cell Donation Experience: is There Room for Improvement?

Overview

Journal Bone Marrow Transplant

Specialty General Surgery

Date 2014 Jan 28

PMID 24464144

Citations 8

Authors

A Billen

J A Madrigal

B E Shaw

Affiliations

Soon will be listed here.

Abstract

Donation of haematopoietic stem cells, either through BM or PBSC collection, is a generally safe procedure for healthy donors although adverse reactions are a definite risk. The invaluable source of donation and its central role in transplantation implies that every effort should be made to alleviate possible difficulties the donor encounters. The physical and psychological reactions to donation have been established for some time, but less is known about the factors that are associated with a poorer donation experience. In this article, we provide an overview of the physical and psychological donation experience and focus attention on demographic, physical and psychological factors that may influence this donation experience. Understanding that toxicity profiles vary with certain donor characteristics is crucial as this knowledge could influence practice in numerous ways including the modification of joining and recruitment policies and the improvement of supportive measures and donor follow-up procedures. Although this review deals with both unrelated and related donors (RDs), there is a relative paucity of regulation of RD care and we call for more attention to this area. Owing to the relative rarity of donation in each country, a global effort to collect donor outcome data is needed.

Citing Articles

Supportive Care of Hematopoietic Stem Cell Donors.

Rennert W, Smith M J, Cormier K, Austin A Clin Hematol Int. 2024; 6(1):43-50.

PMID: 38817695 PMC: 11086998. DOI: 10.46989/001c.92460.

The impact of COVID-19 on related-donor allogeneic stem cell harvest processes: A British Society of Blood and Marrow Transplantation and Cellular Therapy survey.

Wolf J, Lee J, Pearce R, Wilson M, Snowden J, Orchard K Br J Haematol. 2022; 198(4):e51-e53.

PMID: 35655329 PMC: 9347980. DOI: 10.1111/bjh.18299.

Physical and Psychological Discomfort Experienced by Hematopoietic Stem-Cell Donors.

Kim M, Kim T, Beom S Int J Environ Res Public Health. 2020; 17(7).

PMID: 32235487 PMC: 7177619. DOI: 10.3390/ijerph17072316.

Does Being A Cancer Patient or Family Caregiver of A Cancer Patient Affect Stem Cell Donation Awareness?.

Bagcivan G, Ozen N, Bayrak D, Cinar F Asia Pac J Oncol Nurs. 2019; 7(1):36-43.

PMID: 31879682 PMC: 6927162. DOI: 10.4103/apjon.apjon_22_19.

Feasibility and cost analysis of day 4 granulocyte colony-stimulating factor mobilized peripheral blood progenitor cell collection from HLA-matched sibling donors.

Newell L, Shoop K, Knight R, Murray S, Kwock R, Jacoby C Cytotherapy. 2019; 21(7):725-737.

PMID: 31085121 PMC: 7219570. DOI: 10.1016/j.jcyt.2019.04.001.

References

Leitner G, Baumgartner K, Kalhs P, Biener D, Greinix H, Hoecker P . Regeneration, health status and quality of life after rhG-CSF-stimulated stem cell collection in healthy donors: a cross-sectional study. Bone Marrow Transplant. 2008; 43(5):357-63. DOI: 10.1038/bmt.2008.335. View

Horowitz M, Confer D . Evaluation of hematopoietic stem cell donors. Hematology Am Soc Hematol Educ Program. 2005; :469-75. DOI: 10.1182/asheducation-2005.1.469. View

Kodera Y, Yamamoto K, Harada M, Morishima Y, Dohy H, Asano S . PBSC collection from family donors in Japan: a prospective survey. Bone Marrow Transplant. 2013; 49(2):195-200. DOI: 10.1038/bmt.2013.147. View

Butterworth V, Simmons R, Bartsch G, Randall B, Schimmel M, Stroncek D . Psychosocial effects of unrelated bone marrow donation: experiences of the National Marrow Donor Program. Blood. 1993; 81(7):1947-59. View

Favre G, Beksac M, Bacigalupo A, Ruutu T, Nagler A, Gluckman E . Differences between graft product and donor side effects following bone marrow or stem cell donation. Bone Marrow Transplant. 2003; 32(9):873-80. DOI: 10.1038/sj.bmt.1704245. View

Wolcott D, Wellisch D, Fawzy F, Landsverk J . Psychological adjustment of adult bone marrow transplant donors whose recipient survives. Transplantation. 1986; 41(4):484-8. DOI: 10.1097/00007890-198604000-00014. View

Bosi A, Bartolozzi B . Safety of bone marrow stem cell donation: a review. Transplant Proc. 2010; 42(6):2192-4. DOI: 10.1016/j.transproceed.2010.05.029. View

Switzer G, Dew M, Magistro C, Goycoolea J, Twillman R, Alter C . The effects of bereavement on adult sibling bone marrow donors' psychological well-being and reactions to donation. Bone Marrow Transplant. 1998; 21(2):181-8. DOI: 10.1038/sj.bmt.1701063. View

Taenzer A, Clark C, CURRY C . Gender affects report of pain and function after arthroscopic anterior cruciate ligament reconstruction. Anesthesiology. 2000; 93(3):670-5. DOI: 10.1097/00000542-200009000-00015. View

10.

Stroncek D, Clay M, Petzoldt M, Smith J, JASZCZ W, Oldham F . Treatment of normal individuals with granulocyte-colony-stimulating factor: donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells. Transfusion. 1996; 36(7):601-10. DOI: 10.1046/j.1537-2995.1996.36796323059.x. View

11.

Ruau D, Liu L, Clark J, Angst M, Butte A . Sex differences in reported pain across 11,000 patients captured in electronic medical records. J Pain. 2012; 13(3):228-34. PMC: 3293998. DOI: 10.1016/j.jpain.2011.11.002. View

12.

Stroncek D, Holland P, Bartch G, Bixby T, Simmons R, Antin J . Experiences of the first 493 unrelated marrow donors in the National Marrow Donor Program. Blood. 1993; 81(7):1940-6. View

13.

Shaw B . First do no harm. Blood. 2010; 115(24):4978-9. DOI: 10.1182/blood-2010-03-275255. View

14.

Burmeister M, Standl T, Brauer P, Ramsperger K, Kroger N, Zander A . Safety and efficacy of spinal vs general anaesthesia in bone marrow harvesting. Bone Marrow Transplant. 1998; 21(11):1145-8. DOI: 10.1038/sj.bmt.1701235. View

15.

Spierings E, Kim Y, Hendriks M, Borst E, Sergeant R, Canossi A . Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013; 19(8):1244-53. DOI: 10.1016/j.bbmt.2013.06.001. View

16.

van Walraven S, Nicoloso-de Faveri G, Axdorph-Nygell U, Douglas K, Jones D, Lee S . Family donor care management: principles and recommendations. Bone Marrow Transplant. 2009; 45(8):1269-73. DOI: 10.1038/bmt.2009.354. View

17.

Pillay B, Lee S, Katona L, de Bono S, Warren N, Fletcher J . The psychosocial impact of haematopoietic SCT on sibling donors. Bone Marrow Transplant. 2012; 47(10):1361-5. DOI: 10.1038/bmt.2012.22. View

18.

Ayuk F, Zabelina T, Wortmann F, Alchalby H, Wolschke C, Lellek H . Donor choice according to age for allo-SCT for AML in complete remission. Bone Marrow Transplant. 2013; 48(8):1028-32. DOI: 10.1038/bmt.2013.14. View

19.

Siddiq S, Pamphilon D, Brunskill S, Doree C, Hyde C, Stanworth S . Bone marrow harvest versus peripheral stem cell collection for haemopoietic stem cell donation in healthy donors. Cochrane Database Syst Rev. 2009; (1):CD006406. DOI: 10.1002/14651858.CD006406.pub2. View

20.

ODonnell P, Pedersen T, Confer D, Rizzo J, Pulsipher M, Stroncek D . Practice patterns for evaluation, consent, and care of related donors and recipients at hematopoietic cell transplantation centers in the United States. Blood. 2010; 115(24):5097-101. PMC: 2890146. DOI: 10.1182/blood-2010-01-262915. View