Serum Levels of TGF-β1 and MCP-1 As Biomarkers for Progressive Coal Workers' Pneumoconiosis in Retired Coal Workers: a Three-year Follow-up Study

Overview

Journal Ind Health

Specialties Environmental Health
Occupational Medicine

Date 2014 Jan 28

PMID 24464026

Citations 10

Authors

Jong Seong Lee

Jae Hoon Shin

Kyung Myung Lee

Ju-Hwan Hwang

Jin Ee Baek

Ji Hong Kim

Byung-Soon Choi

Affiliations

Soon will be listed here.

Abstract

Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers' pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal workers. To investigate the relevance of serum cytokines in CWP, serum levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) as progressive CWP biomarkers were studied in relation to the progression of pneumoconiosis over a 3 yr period in 85 patients with CWP. CWP progression was evaluated through paired comparisons of chest radiographs. Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-β1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-β1 levels were related to the progression of CWP (β=0.247, p=0.016). The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP.

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