Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor

Overview

Journal Science

Specialty Science

Date 1987 Nov 27

PMID 2446389

Citations 70

Authors

I W Caras

G N Weddell

M A Davitz

V NUSSENZWEIG

D W Martin Jr

Affiliations

Soon will be listed here.

Abstract

Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is covalently attached to the carboxyl terminus of the protein. The last 37 amino acids of membrane DAF, when fused to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the plasma membrane by means of a glycophospholipid anchor. This approach provides a novel means of targeting proteins to the cell-surface membrane.

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