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Insights into MiRNA Regulation of the Human Glycome

Overview
Journal Biochem Biophys Res Commun
Publisher Elsevier
Specialty Biochemistry
Date 2014 Jan 28
PMID 24463102
Citations 20
Authors
Brian T Kasper
Sujeethraj Koppolu
Lara K Mahal
Affiliations
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Abstract

Glycosylation is an intricate process requiring the coordinated action of multiple proteins, including glycosyltransferases, glycosidases, sugar nucleotide transporters and trafficking proteins. Work by several groups points to a role for microRNA (miRNA) in controlling the levels of specific glycosyltransferases involved in cancer, neural migration and osteoblast formation. Recent work in our laboratory suggests that miRNA are a principal regulator of the glycome, translating genomic information into the glycocode through tuning of enzyme levels. Herein we overlay predicted miRNA regulation of glycosylation related genes (glycogenes) onto maps of the common N-linked and O-linked glycan biosynthetic pathways to identify key regulatory nodes of the glycome. Our analysis provides insights into glycan regulation and suggests that at the regulatory level, glycogenes are non-redundant.

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