First Trimester Typhoid Fever with Vertical Transmission of Salmonella Typhi, an Intracellular Organism

Overview

Journal Case Rep Med

Publisher Wiley

Specialty General Medicine

Date 2014 Jan 25

PMID 24459469

Citations 5

Authors

Marguerite B Vigliani

Anna I Bakardjiev

Affiliations

Soon will be listed here.

Abstract

We report a case in which placental abruption occurred at 16 weeks following first trimester diagnosis and treatment for typhoid fever. Unexpectedly Salmonella enterica serovar Typhi (S. Typhi) was found in fetal tissues at autopsy. Using information from the murine model of typhoid fever in pregnancy, we draw parallels between S. Typhi and L. monocytogenes to develop a plausible hypothesis to explain how this organism was able to cross the placenta in the first trimester to cause abruption, inflammation, and expulsion of the fetus and placenta. We hope that this model for understanding placental infections by the hematogenous route helps to raise awareness that organisms not typically associated with TORCH infection can nevertheless cause placental infection and pregnancy loss.

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