The Central Role of EED in the Orchestration of Polycomb Group Complexes

Overview

Journal Nat Commun

Specialty Biology

Date 2014 Jan 25

PMID 24457600

Citations 83

Authors

Qi Cao

Xiaoju Wang

Meng Zhao

Rendong Yang

Rohit Malik

Yuanyuan Qiao

Anton Poliakov

Anastasia K Yocum

Yong Li

Wei Chen

Xuhong Cao

Xia Jiang

Arun Dahiya

Clair Harris

Felix Y Feng

Sundeep Kalantry

Zhaohui S Qin

Saravana M Dhanasekaran

Arul M Chinnaiyan

Affiliations

Soon will be listed here.

Abstract

Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity. Taken together, we suggest an integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2.

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