Protective Effect of Theaflavin on Erythrocytes Subjected to in Vitro Oxidative Stress

Overview

Journal Biochem Res Int

Publisher Wiley

Specialty Biochemistry

Date 2014 Jan 24

PMID 24455262

Citations 12

Authors

Mahejabeen Fatima

Rajesh Kumar Kesharwani

Krishna Misra

Syed Ibrahim Rizvi

Affiliations

Soon will be listed here.

Abstract

Antioxidant and free radical scavenging effect of black tea theaflavins has been shown in many epidemiological studies. In the present work we report the protective mechanism of tea theaflavins on biomarkers of oxidative stress, which are elevated during stress conditions. We hereby report the in vitro effect of theaflavins on erythrocyte malondialdehyde (MDA), intracellular reduced glutathione (GSH), and plasma membrane redox system (PMRS) of rats. The effect of theaflavin on PMRS has also been validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). We report that theaflavins show significant protection to erythrocyte against oxidative stress induced by tert-butyl hydroperoxide (t-BHP). The findings suggest a possible protective role of theaflavins as antioxidant.

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