Matrix Metalloproteinase Gene Polymorphisms and Oral Cancer

Overview

Journal J Clin Exp Dent

Specialty Dentistry

Date 2014 Jan 24

PMID 24455039

Citations 8

Authors

Andresa C Pereira

Elaine Dias do Carmo

Marco A Dias da Silva

Luiz E Blumer Rosa

Affiliations

Soon will be listed here.

Abstract

Since oral squamous cell carcinoma (OSCC) is the most prevalent malignant cancer in the oral cavity, several researches have been performed to study the role of important enzymes in this disease. Among them, the matrix metalloproteinases (MMPs) are highlighted, due to the fact that they are proteinases responsible to degrade many extra-cellular matrix components, making possible the invasion of neoplasic cells. Important tools in cancer prognosis have been utilized aiming to correlate high levels of MMPs and OSCC, such as immunohistochemical, zymographic and mRNA detection methods. However, these techniques are usually applied after cancer detection, characterizing a curative but not a preventive medicine. Trying to make interventions before the development of the disease and making possible the identification of people at high risk and, analysis of modifications in MMP genes has been a chance for modern medicine. Recently, polymorphisms in MMP genes have been related to different neoplasias, including OSCC. Despite investigation is beginning, MMP gene polymorphisms seems to have a promising future in oral cancer research and some of the present results have shown that there are MMP polymorphisms related to an increased risk for developing oral cancer. Key words:Oral cancer, polymorphism, matrix metalloproteinase.

Citing Articles

The Role of the Gene in Tumor Development and Metastasis: A Narrative Review.

Kalali D Glob Med Genet. 2023; 10(2):48-53.

PMID: 37077369 PMC: 10110361. DOI: 10.1055/s-0043-1768166.

Oral Cancer Theranostic Application of FeAu Bimetallic Nanoparticles Conjugated with MMP-1 Antibody.

Tsai M, Sun Y, Keerthi M, Panda A, Dhawan U, Chang Y Nanomaterials (Basel). 2022; 12(1).

PMID: 35010011 PMC: 8746455. DOI: 10.3390/nano12010061.

Deciphering the genetic alterations in matrix metallo-proteinase gene family and its putative association with head and neck squamous cell carcinoma.

Aparna J, Smiline-Girija A, Paramasivam A, Vijayashree-Priyadharsini J Mol Biol Res Commun. 2021; 10(1):13-22.

PMID: 33681393 PMC: 7936386. DOI: 10.22099/mbrc.2020.38344.1544.

Matrix metalloproteinases gene variants and dental caries in Czech children.

Borilova Linhartova P, Deissova T, Kukletova M, Holla L BMC Oral Health. 2020; 20(1):138.

PMID: 32398053 PMC: 7216629. DOI: 10.1186/s12903-020-01130-6.

Association of Common Variants in MMPs with Periodontitis Risk.

Li W, Zhu Y, Singh P, Ajmera D, Song J, Ji P Dis Markers. 2016; 2016:1545974.

PMID: 27194818 PMC: 4853955. DOI: 10.1155/2016/1545974.

References

Vairaktaris E, Vassiliou S, Nkenke E, Serefoglou Z, Derka S, Tsigris C . A metalloproteinase-9 polymorphism which affects its expression is associated with increased risk for oral squamous cell carcinoma. Eur J Surg Oncol. 2007; 34(4):450-5. DOI: 10.1016/j.ejso.2007.03.024. View

Grieu F, Li W, Iacopetta B . Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype. Breast Cancer Res Treat. 2004; 88(3):197-204. DOI: 10.1007/s10549-004-0595-6. View

Awakura Y, Ito N, Nakamura E, Takahashi T, Kotani H, Mikami Y . Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population. Cancer Lett. 2006; 241(1):59-63. DOI: 10.1016/j.canlet.2005.10.005. View

Zhou Y, Yu C, Miao X, Tan W, Liang G, Xiong P . Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. Carcinogenesis. 2003; 25(3):399-404. DOI: 10.1093/carcin/bgh020. View

Jordan R, Macabeo-Ong M, Shiboski C, Dekker N, Ginzinger D, Wong D . Overexpression of matrix metalloproteinase-1 and -9 mRNA is associated with progression of oral dysplasia to cancer. Clin Cancer Res. 2004; 10(19):6460-5. DOI: 10.1158/1078-0432.CCR-04-0656. View

Miao X, Yu C, Tan W, Xiong P, Liang G, Lu W . A functional polymorphism in the matrix metalloproteinase-2 gene promoter (-1306C/T) is associated with risk of development but not metastasis of gastric cardia adenocarcinoma. Cancer Res. 2003; 63(14):3987-90. View

Lin S, Chung M, Huang J, Shieh T, Liu C, Chang K . Correlation between functional genotypes in the matrix metalloproteinases-1 promoter and risk of oral squamous cell carcinomas. J Oral Pathol Med. 2004; 33(6):323-6. DOI: 10.1111/j.1600-0714.2004.00214.x. View

Ikebe T, Shinohara M, Takeuchi H, Beppu M, Kurahara S, Nakamura S . Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer. Clin Exp Metastasis. 1999; 17(4):315-23. DOI: 10.1023/a:1006642428826. View

Lai H, Chu C, Lin Y, Chang C, Nieh S, Yu M . Matrix metalloproteinase 1 gene polymorphism as a prognostic predictor of invasive cervical cancer. Gynecol Oncol. 2005; 96(2):314-9. DOI: 10.1016/j.ygyno.2004.09.065. View

10.

Lin S, Lo S, Liu C, Chung M, Huang J, Chang K . Functional genotype in matrix metalloproteinases-2 promoter is a risk factor for oral carcinogenesis. J Oral Pathol Med. 2004; 33(7):405-9. DOI: 10.1111/j.1600-0714.2004.00231.x. View

11.

Ye S, Watts G, Mandalia S, Humphries S, Henney A . Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis. Br Heart J. 1995; 73(3):209-15. PMC: 483800. DOI: 10.1136/hrt.73.3.209. View

12.

Przybylowska K, Kluczna A, Zadrozny M, Krawczyk T, Kulig A, Rykala J . Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer. Breast Cancer Res Treat. 2005; 95(1):65-72. DOI: 10.1007/s10549-005-9042-6. View

13.

Sorsa T, Tjaderhane L, Salo T . Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 2004; 10(6):311-8. DOI: 10.1111/j.1601-0825.2004.01038.x. View

14.

Rutter J, Mitchell T, Buttice G, Meyers J, Gusella J, Ozelius L . A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. Cancer Res. 1998; 58(23):5321-5. View

15.

Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T . Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem. 2003; 253(1-2):269-85. DOI: 10.1023/a:1026028303196. View

16.

Hinoda Y, Okayama N, Takano N, Fujimura K, Suehiro Y, Hamanaka Y . Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer. Int J Cancer. 2002; 102(5):526-9. DOI: 10.1002/ijc.10750. View

17.

Ghilardi G, Biondi M, Caputo M, Leviti S, DeMonti M, Guagnellini E . A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility. Clin Cancer Res. 2002; 8(12):3820-3. View

18.

Katayama A, Bandoh N, Kishibe K, Takahara M, Ogino T, Nonaka S . Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis. Clin Cancer Res. 2004; 10(2):634-40. DOI: 10.1158/1078-0432.ccr-0864-02. View

19.

Hong S, Hong S, Lee J, Lim C . Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential. Oral Oncol. 2000; 36(2):207-13. DOI: 10.1016/s1368-8375(99)00088-3. View

20.

Hashimoto T, Uchida K, Okayama N, Imate Y, Suehiro Y, Hamanaka Y . Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma. Cancer Lett. 2004; 211(1):19-24. DOI: 10.1016/j.canlet.2004.01.032. View