Impact of Sleep Respiratory Disorders on Endothelial Function in Children

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2014 Jan 24

PMID 24453895

Citations 7

Authors

Luigia Brunetti

Ruggiero Francavilla

Pietro Scicchitano

Valentina Tranchino

Maria Loscialpo

Michele Gesualdo

Annapaola Zito

Fara Fornarelli

Marco Sassara

Paola Giordano

Vito Leonardo Miniello

Marco Matteo Ciccone

Affiliations

Soon will be listed here.

Abstract

Obstructive sleep apnea syndrome (OSAS) in children can induce endothelial dysfunction, a well-known early marker of atherosclerosis. The study aimed to evaluate a link among endothelial function (measured by flow-mediated vasodilation (FMD)), obesity (evaluated by body mass index (BMI)), and sleep disordered breathing (SDB), assessed with apnoea/hypopnoea index (AHI), in a paediatric population. We demonstrated that our little OSAS patients showed an impaired endothelial function as compared to controls. In particular, the higher the AHI, the worst the FMD values and thus the endothelial function. Although the population sample is small, this study demonstrated that OSAS could impair endothelial function and worsen cardiovascular risk profile since childhood.

Citing Articles

Cardiovascular Disorders Triggered by Obstructive Sleep Apnea-A Focus on Endothelium and Blood Components.

Mochol J, Gawrys J, Gajecki D, Szahidewicz-Krupska E, Martynowicz H, Doroszko A Int J Mol Sci. 2021; 22(10).

PMID: 34066288 PMC: 8152030. DOI: 10.3390/ijms22105139.

The cardiovascular risk in paediatrics: the paradigm of the obstructive sleep apnoea syndrome.

Zaffanello M, Piacentini G, La Grutta S Blood Transfus. 2020; 18(3):217-225.

PMID: 32203011 PMC: 7250680. DOI: 10.2450/2020.0283-19.

Memory performances and personality traits in mothers of children with obstructive sleep apnea syndrome.

Smirni D, Carotenuto M, Precenzano F, Smirni P, Operto F, Marotta R Psychol Res Behav Manag. 2019; 12:481-487.

PMID: 31303802 PMC: 6611713. DOI: 10.2147/PRBM.S202469.

The predictive value of polysomnography combined with quality of life for treatment decision of children with habitual snoring related to adenotonsillar hypertrophy.

Zhao G, Li Y, Wang X, Ding X, Wang C, Xu W Eur Arch Otorhinolaryngol. 2018; 275(6):1579-1586.

PMID: 29696368 DOI: 10.1007/s00405-018-4984-6.

Longitudinal Cardiovascular Outcomes of Sleep Disordered Breathing in Children: A Meta-Analysis and Systematic Review.

Ehsan Z, Ishman S, Kimball T, Zhang N, Zou Y, Amin R Sleep. 2017; 40(3).

PMID: 28329042 PMC: 6251700. DOI: 10.1093/sleep/zsx015.

References

Nieminen P, Tolonen U, Lopponen H, Lopponen T, Luotonen J, Jokinen K . Snoring children: factors predicting sleep apnea. Acta Otolaryngol Suppl. 1997; 529:190-4. DOI: 10.3109/00016489709124119. View

Bhattacharjee R, Kim J, Kheirandish-Gozal L, Gozal D . Obesity and obstructive sleep apnea syndrome in children: a tale of inflammatory cascades. Pediatr Pulmonol. 2010; 46(4):313-23. DOI: 10.1002/ppul.21370. View

Li A, Chan D, Wong E, Yin J, Nelson E, Fok T . The effects of obesity on pulmonary function. Arch Dis Child. 2003; 88(4):361-3. PMC: 1719520. DOI: 10.1136/adc.88.4.361. View

Gozal D, Kheirandish-Gozal L, Bhattacharjee R, Spruyt K . Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea. Pediatrics. 2010; 126(5):e1161-7. DOI: 10.1542/peds.2010-0688. View

Muzumdar H, Arens R . Diagnostic issues in pediatric obstructive sleep apnea. Proc Am Thorac Soc. 2008; 5(2):263-73. PMC: 2645257. DOI: 10.1513/pats.200707-113MG. View

Villa M, Brunetti L, Bruni O, Cirignotta F, Cozza P, Donzelli G . [Guidelines for the diagnosis of childhood obstructive sleep apnea syndrome]. Minerva Pediatr. 2004; 56(3):239-53. View

Shapiro G, Shapiro C . Factors that influence CPAP adherence: an overview. Sleep Breath. 2010; 14(4):323-35. DOI: 10.1007/s11325-010-0391-y. View

Brunetti L, Rana S, Lospalluti M, Pietrafesa A, Francavilla R, Fanelli M . Prevalence of obstructive sleep apnea syndrome in a cohort of 1,207 children of southern Italy. Chest. 2001; 120(6):1930-5. DOI: 10.1378/chest.120.6.1930. View

Marcus C . Childhood obstructive sleep apnea syndrome: unanswered questions. Chest. 2008; 134(6):1114-1115. DOI: 10.1378/chest.08-2011. View

10.

Gozal D, Kheirandish-Gozal L, Serpero L, Sans Capdevila O, Dayyat E . Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy. Circulation. 2007; 116(20):2307-14. DOI: 10.1161/CIRCULATIONAHA.107.696823. View

11.

Nena E, Steiropoulos P, Papanas N, Tsara V, Fitili C, Froudarakis M . Sleepiness as a marker of glucose deregulation in obstructive sleep apnea. Sleep Breath. 2011; 16(1):181-6. DOI: 10.1007/s11325-010-0472-y. View

12.

Ohayon M, CAULET M, Priest R, Guilleminault C . DSM-IV and ICSD-90 insomnia symptoms and sleep dissatisfaction. Br J Psychiatry. 1997; 171:382-8. DOI: 10.1192/bjp.171.4.382. View

13.

Rosen C, DAndrea L, Haddad G . Adult criteria for obstructive sleep apnea do not identify children with serious obstruction. Am Rev Respir Dis. 1992; 146(5 Pt 1):1231-4. DOI: 10.1164/ajrccm/146.5_Pt_1.1231. View

14.

Lanfranco F, Motta G, Minetto M, Baldi M, Balbo M, Ghigo E . Neuroendocrine alterations in obese patients with sleep apnea syndrome. Int J Endocrinol. 2010; 2010:474518. PMC: 2826879. DOI: 10.1155/2010/474518. View

15.

Brunetti L, Tesse R, Miniello V, Colella I, Delvecchio M, Logrillo V . Sleep-disordered breathing in obese children: the southern Italy experience. Chest. 2010; 137(5):1085-90. DOI: 10.1378/chest.09-1529. View

16.

Dayyat E, Kheirandish-Gozal L, Gozal D . Childhood Obstructive Sleep Apnea: One or Two Distinct Disease Entities?. Sleep Med Clin. 2008; 2(3):433-444. PMC: 2084206. DOI: 10.1016/j.jsmc.2007.05.004. View

17.

Larkin E, Rosen C, Kirchner H, Storfer-Isser A, Emancipator J, Johnson N . Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration. Circulation. 2005; 111(15):1978-84. DOI: 10.1161/01.CIR.0000161819.76138.5E. View

18.

Kheirandish-Gozal L, Bhattacharjee R, Gozal D . Autonomic alterations and endothelial dysfunction in pediatric obstructive sleep apnea. Sleep Med. 2010; 11(7):714-20. DOI: 10.1016/j.sleep.2009.12.013. View

19.

Carroll J, McColley S, Marcus C, Curtis S, Loughlin G . Inability of clinical history to distinguish primary snoring from obstructive sleep apnea syndrome in children. Chest. 1995; 108(3):610-8. DOI: 10.1378/chest.108.3.610. View

20.

Guilleminault C . Obstructive sleep apnea syndrome. A review. Psychiatr Clin North Am. 1987; 10(4):607-21. View