Preimplantation Genetic Testing in the 21st Century: Uncharted Territory

Overview

Journal Clin Med Insights Reprod Health

Publisher Sage Publications

Specialty Reproductive Medicine

Date 2014 Jan 24

PMID 24453515

Citations 2

Authors

Paul R Brezina

Affiliations

Soon will be listed here.

Abstract

The past hundred years have given birth to arguably the most profound changes in society, medicine, and technology the world has ever witnessed. Genetics is one such field that has enjoyed a meteoric rise during this time. Progressing from Mendelian genetics to the discovery of DNA to the ability to sequence the human genome, perhaps no other discipline holds more promise to affect future change than genetics. Technology currently exists to evaluate some of the genetic information held by developing embryos in the context of an in vitro fertilization (IVF) cycle. This information is then used to determine which embryos are selected for uterine transfer. Many societies have enacted legislation to protect against possible abuses utilizing this technology. However, it is incumbent upon society to continue ensuring that preimplantation genetic diagnosis (PGD)-and genetic testing in general-is applied in a way that utilizes its potential in a responsible manner to improve health care.

Citing Articles

Genetics in human reproduction.

Rodrigues V, Polisseni F, Pannain G, Carvalho M JBRA Assist Reprod. 2020; 24(4):480-491.

PMID: 32293822 PMC: 7558894. DOI: 10.5935/1518-0557.20200007.

Preliminary trials of a specific gravity technique in the determination of early embryo growth potential†.

Prien S, Wessels C, Penrose L Hum Reprod. 2015; 30(9):2076-83.

PMID: 26202920 PMC: 4542720. DOI: 10.1093/humrep/dev178.

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