Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2014 Jan 24

PMID 24451251

Citations 84

Authors

Patricia G G do Nascimento

Telma L G Lemos

Ayla M C Bizerra

Angela M C Arriaga

Daniele A Ferreira

Gilvandete M P Santiago

Raimundo Braz-Filho

Jose Galberto M Costa

Affiliations

Soon will be listed here.

Abstract

Ursolic acid, an important bioactive compound, was isolated from ethanol extract of aerial parts of Sambucus australis. In order to develop bioactive ursolic acid derivatives, two semi-synthetic compounds were obtained through modification at C-3. The antibacterial activity of the ursolic acid and its derivatives was investigated. The microdilution method was used for determination of the minimal inhibitory concentration (MIC), against twelve bacterial strains. The influence of ursolic acid and its derivatives on the susceptibility of some bacterial pathogens to the aminoglycosides antibiotics neomycin, amikacin, kanamycin and gentamicin was evaluated. The most representative synergistic effect was observed by 3β-formyloxy-urs-12-en-28-oic acid at the concentration of 64 μg/mL in combination with kanamycin against Escherichia coli (27), a multidrug-resistant clinical isolate from sputum, with reduction of MIC value from 128 μg/mL to 8 μg/mL. Ursolic acid and its derivatives were examined for their radical scavenger activity using the DPPH assay, and showed significant activity.

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