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Orthotopic Liver Transplantation in Dogs Receiving FK-506

Overview
Journal Transplant Proc
Specialty General Surgery
Date 1987 Oct 1
PMID 2445079
Citations 29
Authors
S Todo
L Podesta
P Chapchap
D Kahn
C E Pan
Y Ueda
K Okuda
O Imventarza
A Casavilla
A J Demetris
Affiliations
Soon will be listed here.
Abstract

Ten dogs that survived the perioperative events of liver transplantation were treated with 1 mg/kg/d oral FK. Eight of the recipients lived for at least 1 month postoperatively, and seven are still alive with normal hepatic function after 35 to 65 days. The consistency and good quality of results with this difficult transplant preparation using FK, in spite of its rumored great toxicity in dogs, have highlighted the importance of further developing the drug.

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References
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Todo S, Makowka L, Starzl T . IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION. Surg Res Commun. 2011; 1:333-340. PMC: 3089006. View
2.
Ochiai T, Nakajima K, Nagata M, Suzuki T, Asano T, Uematsu T . Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc. 1987; 19(1 Pt 2):1284-6. View
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Lee P, Murase N, Todo S, Makowka L, Starzl T . THE IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 IN RATS RECEIVING HETEROTOPIC CARDIAC ALLOGRAFTS. Surg Res Commun. 2011; 1:325-331. PMC: 3089005. View
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Ochiai T, Nakajima K, Nagata M, Hori S, Asano T, Isono K . Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation. 1987; 44(6):734-8. DOI: 10.1097/00007890-198712000-00002. View
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Todo S, Porter K, Kam I, Lynch S, Venkataramanan R, Dewolf A . Canine liver transplantation under Nva2-cyclosporine versus cyclosporine. Transplantation. 1986; 41(3):296-300. PMC: 2952471. DOI: 10.1097/00007890-198603000-00004. View