Molecular Basis of Cardiac Myxomas

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2014 Jan 23

PMID 24447924

Citations 17

Authors

Pooja Singhal

Adriana Luk

Vivek Rao

Jagdish Butany

Affiliations

Soon will be listed here.

Abstract

Cardiac tumors are rare, and of these, primary cardiac tumors are even rarer. Metastatic cardiac tumors are about 100 times more common than the primary tumors. About 90% of primary cardiac tumors are benign, and of these the most common are cardiac myxomas. Approximately 12% of primary cardiac tumors are completely asymptomatic while others present with one or more signs and symptoms of the classical triad of hemodynamic changes due to intracardiac obstruction, embolism and nonspecific constitutional symptoms. Echocardiography is highly sensitive and specific in detecting cardiac tumors. Other helpful investigations are chest X-rays, magnetic resonance imaging and computerized tomography scan. Surgical excision is the treatment of choice for primary cardiac tumors and is usually associated with a good prognosis. This review article will focus on the general features of benign cardiac tumors with an emphasis on cardiac myxomas and their molecular basis.

Citing Articles

Detection of PRKAR1A gene mutations in sporadic cardiac myxomas: a study of 24 cases.

Bekers E, van Bladel D, Berendsen M, Eijkelenboom A, van Krieken J, Ooft M Virchows Arch. 2025; .

PMID: 39966109 DOI: 10.1007/s00428-025-04049-x.

Position-triggered embolic events in cardiac myxoma: a description of two cases.

Zhang H, Yan D, Song X, He X, Yang Y, Wang C Quant Imaging Med Surg. 2024; 14(12):9738-9745.

PMID: 39698642 PMC: 11651998. DOI: 10.21037/qims-24-1003.

Preoperative management and anticoagulant efficacy in atrial myxoma-associated acute ischemic stroke: a case report and literature review.

Chen Y, Huang Q, Bai C, Zhang H, Zhang B Front Cardiovasc Med. 2024; 11:1435047.

PMID: 39600609 PMC: 11588714. DOI: 10.3389/fcvm.2024.1435047.

The benign nature and rare occurrence of cardiac myxoma as a possible consequence of the limited cardiac proliferative/ regenerative potential: a systematic review.

Shafi O, Siddiqui G, Jaffry H BMC Cancer. 2023; 23(1):1245.

PMID: 38110859 PMC: 10726542. DOI: 10.1186/s12885-023-11723-3.

Cardiac myxomas: causes, presentations, diagnosis, and management.

Saad E, Mukherjee T, Gandour G, Fatayerji N, Rammal A, Samuel P Ir J Med Sci. 2023; 193(2):677-688.

PMID: 37737916 DOI: 10.1007/s11845-023-03531-2.

References

Kang N, Hughes C . Massive pulmonary embolus complicating left atrial myxoma. J Thorac Cardiovasc Surg. 2001; 121(4):814-5. DOI: 10.1067/mtc.2001.111195. View

Byrd W, Matthews O, Hunt R . Left atrial myxoma presenting as a systemic vasculitis. Arthritis Rheum. 1980; 23(2):240-3. DOI: 10.1002/art.1780230216. View

Turkmen N, Eren B, Fedakar R, Comunoglu N . An unusual cause of sudden death: cardiac myxoma. Adv Ther. 2007; 24(3):529-32. DOI: 10.1007/BF02848775. View

Pucci A, Gagliardotto P, Zanini C, Pansini S, Di Summa M, Mollo F . Histopathologic and clinical characterization of cardiac myxoma: review of 53 cases from a single institution. Am Heart J. 2000; 140(1):134-8. DOI: 10.1067/mhj.2000.107176. View

Sakamoto H, Sakamaki T, Kanda T, Tsuchiya Y, Sato M, Sato H . Vascular endothelial growth factor is an autocrine growth factor for cardiac myxoma cells. Circ J. 2004; 68(5):488-93. DOI: 10.1253/circj.68.488. View

Vaideeswar P, Butany J . Benign cardiac tumors of the pluripotent mesenchyme. Semin Diagn Pathol. 2008; 25(1):20-8. DOI: 10.1053/j.semdp.2007.10.005. View

Miller D, Tazelaar H, Handy J, Young D, Hernandez J . Thymoma arising within cardiac myxoma. Am J Surg Pathol. 2005; 29(9):1208-13. DOI: 10.1097/01.pas.0000158398.65190.7b. View

Sughimoto K, Shiikawa A, Ohkado A, Nanaumi M . Multiple cardiac myxomas with pulmonary arterial obstruction and acute right heart failure. Jpn J Thorac Cardiovasc Surg. 2004; 52(11):530-3. DOI: 10.1007/s11748-004-0005-3. View

Paraskevaidis I, Michalakeas C, Papadopoulos C, Anastasiou-Nana M . Cardiac tumors. ISRN Oncol. 2011; 2011:208929. PMC: 3195386. DOI: 10.5402/2011/208929. View

10.

Gulati G, Sharma S, Kothari S, Juneja R, Saxena A, Talwar K . Comparison of echo and MRI in the imaging evaluation of intracardiac masses. Cardiovasc Intervent Radiol. 2004; 27(5):459-69. DOI: 10.1007/s00270-004-0123-4. View

11.

Vernon S, Bejarano P . Low-grade fibromyxoid sarcoma: a brief review. Arch Pathol Lab Med. 2006; 130(9):1358-60. DOI: 10.5858/2006-130-1358-LFSABR. View

12.

Mazzola A, Spano J, Valente M, Gregorini R, Villani C, Di Eusanio M . Leiomyosarcoma of the left atrium mimicking a left atrial myxoma. J Thorac Cardiovasc Surg. 2006; 131(1):224-6. DOI: 10.1016/j.jtcvs.2005.07.061. View

13.

Rickelt S, Rizzo S, Doerflinger Y, Zentgraf H, Basso C, Gerosa G . A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. Mod Pathol. 2010; 23(11):1429-37. DOI: 10.1038/modpathol.2010.138. View

14.

Bilku R, Loubani M, Been M, Patel R . Massive right atrial myxoma causing exertional dyspnoea. Eur J Echocardiogr. 2007; 9(1):130-2. DOI: 10.1016/j.euje.2007.04.009. View

15.

Skamrov A, Nechaenko M, Goryunova L, Feoktistova E, Khaspekov G, Kovalevsky D . Gene expression analysis to identify mRNA markers of cardiac myxoma. J Mol Cell Cardiol. 2004; 37(3):717-33. DOI: 10.1016/j.yjmcc.2004.06.006. View

16.

Yamaguchi T, Dumont D, Conlon R, Breitman M, Rossant J . flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development. 1993; 118(2):489-98. DOI: 10.1242/dev.118.2.489. View

17.

Donato G, Conforti F, Zuccala V, Russo E, Maltese L, Perrotta I . Expression of tenascin-c and CD44 receptors in cardiac myxomas. Cardiovasc Pathol. 2008; 18(3):173-7. DOI: 10.1016/j.carpath.2008.03.006. View

18.

Suvarna S, Royds J . The nature of the cardiac myxoma. Int J Cardiol. 1996; 57(3):211-6. DOI: 10.1016/s0167-5273(96)02827-6. View

19.

Narin B, Arman A, Arslan D, Simsek M, Narin A . Assessment of cardiac masses: magnetic resonance imaging versus transthoracic echocardiography. Anadolu Kardiyol Derg. 2010; 10(1):69-74. DOI: 10.5152/akd.2010.016. View

20.

Matyakhina L, Pack S, Kirschner L, Pak E, Mannan P, Jaikumar J . Chromosome 2 (2p16) abnormalities in Carney complex tumours. J Med Genet. 2003; 40(4):268-77. PMC: 1735422. DOI: 10.1136/jmg.40.4.268. View