Effects of Perinatal Bisphenol A Exposure During Early Development on Radial Arm Maze Behavior in Adult Male and Female Rats

Overview

Journal Neurotoxicol Teratol

Specialties Neurology
Toxicology

Date 2014 Jan 21

PMID 24440629

Citations 17

Authors

Renee N Sadowski

Pul Park

Steven L Neese

Duncan C Ferguson

Susan L Schantz

Janice M Juraska

Affiliations

Soon will be listed here.

Abstract

Previous work has shown that exposure to bisphenol A (BPA) can affect anxiety behavior. However, no studies have examined whether administration of this endocrine disruptor during the perinatal period has the potential to induce alterations in cognitive behavior in both adult males and females as assessed in an appetitive task. The goal of the current study was to determine whether exposure to different doses of BPA during early development alters performance on the 17-arm radial maze in adulthood in Long-Evans rats. Oral administration of corn oil (vehicle), 4 μg/kg, 40 μg/kg, or 400 μg/kg BPA to the dams occurred daily throughout pregnancy, and the pups received direct oral administration of BPA between postnatal days 1-9. Blood was collected from offspring at weaning age to determine levels of several hormones (thyroxine, thyroid stimulating hormone, follicle stimulating hormone, luteinizing hormone). One male and one female from each litter were evaluated on the 17-arm radial maze, a working/reference memory task, in adulthood. Results indicated that after exposure to BPA at both 4 and 400 μg/kg/day, rats of both sexes had decreased levels of FSH at weaning. There were no significant effects of BPA on performance on the radial arm maze in males or females. In conclusion, exposure to BPA during early development had modest effects on circulating hormones but did not affect performance on a spatial learning and memory task.

Citing Articles

An Overview of the Health Effects of Bisphenol A from a One Health Perspective.

Molina-Lopez A, Bujalance-Reyes F, Ayala-Soldado N, Mora-Medina R, Lora-Benitez A, Moyano-Salvago R Animals (Basel). 2023; 13(15).

PMID: 37570248 PMC: 10417040. DOI: 10.3390/ani13152439.

Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.

Lambre C, Barat Baviera J, Bolognesi C, Chesson A, Cocconcelli P, Crebelli R EFSA J. 2023; 21(4):e06857.

PMID: 37089179 PMC: 10113887. DOI: 10.2903/j.efsa.2023.6857.

Counteracting Environmental Chemicals with Coenzyme Q10: An Educational Primer for Use with "Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Germline".

Bradford B, Briand N, Fassnacht N, Gervasio E, Nowakowski A, FitzGibbon T Genetics. 2020; 216(4):879-890.

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Effects of Bisphenols on Testicular Steroidogenesis.

Barbagallo F, Condorelli R, Mongioi L, Cannarella R, Aversa A, Calogero A Front Endocrinol (Lausanne). 2020; 11:373.

PMID: 32714277 PMC: 7344146. DOI: 10.3389/fendo.2020.00373.

Bisphenols and Thyroid Hormone.

Kim M, Park Y Endocrinol Metab (Seoul). 2019; 34(4):340-348.

PMID: 31884733 PMC: 6935774. DOI: 10.3803/EnM.2019.34.4.340.

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