Crystalloid Bodies in Skeletal Muscle of Hypothyroid Myopathy. Ultrastructural and Histochemical Studies

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1987 Jan 1

PMID 2444062

Citations 1

Authors

K L Ho

Affiliations

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Abstract

Crystalloid bodies in skeletal muscle fibers have been described in myopathic and non-myopathic conditions. They have been interpreted as viral, glycogen, protein-glycogen complex, artifacts and of unknown nature. This report described similar crystalloid bodies in the postmortem muscle samples of two patients with hypothyroid myopathy. The crystalloid bodies were preferentially located in the I band and Z line region and in the subsarcolemmal region closely associated with lipofuscin. Some were present within basophilic bodies. They were formed by parallel filaments of 6-10 nm beaded periodically by electron-dense particles of 10-18 nm in a lattice, hexagonal or parallel-ripple pattern. Merging of filaments of crystalloid bodies into actin filaments of the I band was noted. The electron-dense particles stained strongly with periodic acid-thiocarbohydrazide-silver proteinate method for polysaccharides and were unaffected or partially digested by diastase treatment on the ultrathin sections. The filamentous component was neither stained for polysaccharides nor digested by diastase treatment. It is suggested that crystalloid bodies of muscle fibers are composed of two distinct subunits with particles of glycogen complex attached to filaments of unknown nature.

Citing Articles

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PMID: 21414784 PMC: 5210189. DOI: 10.1016/j.nmd.2011.02.009.

References

Alvira M, Mendoza M . Letter: Reye's syndrome: a viral myopathy?. N Engl J Med. 1975; 292(24):1297. DOI: 10.1056/nejm197506122922417. View

Tang T, Sedmak G, SIEGESMUND K, MCCREADIE S . Chronic myopathy associated with coxsackievirus type A9. A combined electron microscopical and viral isolation study. N Engl J Med. 1975; 292(12):608-11. DOI: 10.1056/NEJM197503202921203. View

Hurwitz L, McCormick D, ALLEN I . Reduced muscle alpha-glucosidase (acid-maltase) activity in hypothyroid myopathy. Lancet. 1970; 1(7637):67-9. DOI: 10.1016/s0140-6736(70)91849-0. View

Galloway P, Perry G, Gambetti P . Hirano body filaments contain actin and actin-associated proteins. J Neuropathol Exp Neurol. 1987; 46(2):185-99. DOI: 10.1097/00005072-198703000-00006. View

CAULFIELD J, Rebeiz J, Adams R . Viral involvement of human muscle. J Pathol Bacteriol. 1968; 96(1):232-4. DOI: 10.1002/path.1700960128. View

Green R, Webb J, Maxwell M . The nature of virus-like particles in the paraxial muscles of idiopathic scoliosis. J Pathol. 1979; 129(1):9-12. DOI: 10.1002/path.1711290103. View

Hirano A, DEMBITZER H, Kurland L, Zimmerman H . The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and "rod-like" structures as seen in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex. J Neuropathol Exp Neurol. 1968; 27(2):167-82. View

Schiller H, MAIR W . Ultrastructural changes of muscle in malignant hyperthermia. J Neurol Sci. 1974; 21(1):93-100. DOI: 10.1016/0022-510x(74)90109-9. View

McKeran R, Slavin G, Ward P, Paul E, MAIR W . Hypothyroid myopathy. A clinical and pathologaical study. J Pathol. 1980; 132(1):35-54. DOI: 10.1002/path.1711320105. View

10.

De Reuck J, De Coster W, Inderadjaja N . Acute viral polymyositis with predominant diaphragm involvement. J Neurol Sci. 1977; 33(3):453-60. DOI: 10.1016/0022-510x(77)90140-x. View

11.

MCDANIEL H, Pittman C, Oh S, DiMauro S . Carbohydrate metabolism in hypothyroid myopathy. Metabolism. 1977; 26(8):867-73. DOI: 10.1016/0026-0495(77)90005-1. View

12.

Hanson P, Urizar R . Letter: Reye's syndrome--virus or artifact in muscle?. N Engl J Med. 1975; 293(10):505-6. DOI: 10.1056/NEJM197509042931017. View

13.

NORRIS Jr F, Dramov B, Calder C, Johnson S . Virus-like particles in myositis accompanying herpes zoster. Arch Neurol. 1969; 21(1):25-31. DOI: 10.1001/archneur.1969.00480130039004. View

14.

Martinez A, Hay S, MCNEER K . Extraocular muscles: light microscopy and ultrastructural features. Acta Neuropathol. 1976; 34(3):237-53. DOI: 10.1007/BF00688678. View

15.

Culebras A, Merk F . Cytoplasmic inclusion bodies in superior rectus muscle of the eye. Neurology. 1975; 25(5):423-9. DOI: 10.1212/wnl.25.5.422. View

16.

Ho K . Basophilic degeneration of skeletal muscle in hypothyroid myopathy. Histochemical and ultrastructural studies. Arch Pathol Lab Med. 1984; 108(3):239-45. View

17.

Ben-Bassat M, Machtey I . Picornavirus-like structures in acute dermatomyositis. Am J Clin Pathol. 1972; 58(3):245-9. DOI: 10.1093/ajcp/58.3.245. View

18.

Chou S, Gutmann L . Picornavirus-like crystals in subacute polymyositis. Neurology. 1970; 20(3):205-13. DOI: 10.1212/wnl.20.3.205. View

19.

Fukuhara N . Electron microscopical demonstration of nucleic acids in virus-like particles in the skeletal muscle of a traffic accident victim. Acta Neuropathol. 1979; 47(1):55-9. DOI: 10.1007/BF00698273. View

20.

Mastaglia F, Walton J . Coxsackie virus-like particles in skeletal muscle from a case of polymyositis. J Neurol Sci. 1970; 11(6):593-9. DOI: 10.1016/0022-510x(70)90109-7. View