T Cell Ageing: Effects of Age on Development, Survival & Function

Overview

Journal Indian J Med Res

Specialty General Medicine

Date 2014 Jan 18

PMID 24434315

Citations 80

Authors

Nasir Salam

Sanket Rane

Rituparna Das

Matthew Faulkner

Rupali Gund

Usha Kandpal

Virginia Lewis

Hamid Mattoo

Savit Prabhu

Vidya Ranganathan

Jeannine Durdik

Anna George

Satyajit Rath

Vineeta Bal

Affiliations

Soon will be listed here.

Abstract

Age associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population.

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