Therapeutic Implications of Immunogenic Cell Death in Human Cancer

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2014 Jan 17

PMID 24432020

Citations 15

Authors

Fabio Palombo

Chiara Focaccetti

Vincenzo Barnaba

Affiliations

Soon will be listed here.

Abstract

Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.

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