Association of MiR-146a Gene Polymorphism with Risk of Nasopharyngeal Carcinoma in the Central-southern Chinese Population

Overview

Journal J Hum Genet

Specialty Genetics

Date 2014 Jan 17

PMID 24430575

Citations 13

Authors

Guo-Liang Huang

Mei-Ling Chen

Ya-Zhen Li

Yan Lu

Xing-Xiang Pu

Yu-Xiang He

Shu-Yin Tang

Hua Che

Ying Zou

Congcong Ding

Zhiwei He

Affiliations

Soon will be listed here.

Abstract

This case-control study focused on estimating the association between miR-146a polymorphism and risk of nasopharyngeal carcinoma (NPC) in central-south China. In total, 160 patients with NPC and 200 healthy controls in central-south China were genotyped using polymerase chain reaction-restriction fragment length polymorphism assay. Chi-square test was used to assess the different distribution of miR-146a polymorphism between NPC patients and controls; and logistic regression analysis was applied to analyze the associations between miR-146a polymorphism with cancer risk in different contrast models. Significant differences between NPC patients and controls were found in genotype (P=0.033 for GG versus CG versus CC; and odds ratio (OR)=0.568, 95% confidence interval (CI)=0.354-0.912, P=0.019 for CG versus CC; and OR=0.503, 95% CI=0.261-0.971, P=0.041 for CG versus CC; and OR=0.564, 95% CI=0.360-0.884, P=0.012 for GG+CG versus CC, respectively) and allelic analysis (P=0.025 for G versus C). Our findings suggested that polymorphism of mir-146a was associated with NPC in the central-southern Chinese population.

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